Ewha Medical Journal

[English]

Primary breast leiomyosarcoma—pathological challenges and immunohistochemical insights in diagnosing a rare tumor: a case report: Ashwini Pitambra, Ashutosh Rath, Immanuel Pradeep, Krishna Ramavath, Chandramouli Ramalingam; Received March 5, 2026 Accepted April 24, 2026 Published online June 15, 2026; DOI: https://doi.org/10.12771/emj.2026.01249 [Epub ahead of print]

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Primary leiomyosarcoma of the breast is an extremely rare malignancy, accounting for less than 1% of all breast tumors. Diagnosis is challenging because its morphology overlaps with that of other spindle cell lesions, and standardized treatment guidelines are currently unavailable. A 44-year-old woman presented with a rapidly enlarging, firm, 14.8 cm mass in the left breast. She had previously undergone surgery elsewhere, with diagnoses of leiomyoma and desmoid-type fibromatosis. Imaging demonstrated a lobulated mass without evidence of metastasis. Excision revealed pleomorphic spindle cells arranged in intersecting fascicles, with necrosis and dermal invasion. Primary breast leiomyosarcoma was confirmed by immunohistochemistry, which demonstrated smooth muscle actin and desmin positivity and negative staining for pancytokeratin, p63, S100, CD34, and BCL2. The patient underwent modified radical mastectomy followed by adjuvant radiotherapy and chemotherapy. Primary breast leiomyosarcoma is a rare entity that remains diagnostically challenging. Immunohistochemistry is essential for accurate diagnosis, and optimal management requires a dedicated multidisciplinary approach.

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[English]

The Mixed Hepatocellular-Cholangiocarcinoma Confirmed by Liver and Neck Node Biopsy: Hye Won Kang, Jae Jung Park, Il Hwan Moon, Seo Woo Kim, Hyun Kyung Kim, Hyun Jung Oh, Go Heun Kim, Yoon Jung Choi, Hyun Mi Huh, Young Wook Roh, Tae Hun Kim, Kwon Yoo, Ji Yoon Bae, Dong Eun Song; Ihwa Ŭidae chi 2009;32(2):79-84. Published online September 30, 2009; DOI: https://doi.org/10.12771/emj.2009.32.2.79

Abstract
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Mixed hepatocellular-cholangiocarcinoma accounts for about 1% of all hepatocellular carcinoma. In many cases, mixed hepatocellular-cholangiocarcinoma has been misdiagnosed as hepatocellular carcinoma or cholangiocarcinoma because of the indistinctive clinical course and radiologic findings. The clinical course and the pathologic characters are not known well, but it resembles the characteristics of hepatocellularcarcinoma rather than cholangiocarcinoma. So mixed hepatocellular-cholangiocarcinoma was classified as a kind of hepatocellular carcinoma. But the growth and dissemination rate is faster than that of hepatocellular carcinoma and the prognosis more poor. So the exact diagnosis is important. Authors experienced a patient who has the mixed hepatocellular-cholangiocarcinoma diagnosed by liver and neck node biopsy in patient who complain-ed abdominal discomfort and palpable mass, so we report the case.

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A Case of Curative Resection of Advanced Combined Hepatocellular-cholangiocarcinoma after Neoadjuvant Chemotherapy
Jee Eun Choi, Kyung Hee Kim, Seon A Kim, Jung Hwan Lee, Sang Myung Woo, Sang-Jae Park, Eun Kyung Hong, Woo Jin Lee
Korean Journal of Pancreas and Biliary Tract.2016; 21(2): 101. CrossRef

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[English]

Analysis of Histopathological Findings of Hirschsprung's Disease: Immunohistochemical Studies Including GDNF and Cathepsin D: Heasoo Koo, Kum-Ja Choi; Ihwa Ŭidae chi 2003;26(1):7-14. Published online March 31, 2003; DOI: https://doi.org/10.12771/emj.2003.26.1.7

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No abstract available in English.

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Histopathological Evaluation of Pediatric Intestinal Pseudo-Obstruction: Quantitative Morphometric Analysis of Pathological Changes in the Enteric Nervous System
Hyung Kyung Kim, Harin Cheong, Hanna Kang, Ji Yoon Bae, Dong Eun Song, Min Sun Cho, Sun Hee Sung, Woon Sup Han, Heasoo Koo
The Korean Journal of Pathology.2010; 44(2): 162. CrossRef