The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

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• Publication status and reporting quality of case reports on acupuncture-related adverse events: A systematic reviews of case studies
  Tae-Hun Kim, Myeong Soo Lee, Stephen Birch, Terje Alræk, Arne Johan Norheim, Jung Won Kang
  Heliyon.2023; 9(10): e20577.     CrossRef
• A Fatal Case of Bacteremia Caused by Vibrio cholerae Non-O1/O139
  Soyoon Hwang, Yoonjung Kim, Hyejin Jung, Hyun-Ha Chang, Su-Jeong Kim, Han-Ki Park, Jong-Myung Lee, Hye-In Kim, Shin-Woo Kim
  Infection & Chemotherapy.2021; 53(2): 384.     CrossRef
• Non-O1, non-O139 Vibrio cholerae bacteremic skin and soft tissue infections
  Sofia Maraki, Athanasia Christidou, Maria Anastasaki, Efstathia Scoulica
  Infectious Diseases.2016; 48(3): 171.     CrossRef
• The Reporting Quality of Acupuncture-Related Infections in Korean Literature: A Systematic Review of Case Studies
  Tae-Hun Kim, Jung Won Kang, Wan-Soo Park
  Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
• Vibrio Vulnificus Necrotizing Fasciitis Associated with Acupuncture
  Yael Kotton, Soboh Soboh, Naiel Bisharat
  Infectious Disease Reports.2015; 7(3): 5901.     CrossRef