, Mi Ae Lee, Ho Jung Kang, Jeong Hee Hahm Contact dermatitis is a common clinical problem and frequently caused by cosmetics. Detection of causative allergen is important in prevention and treatment of this disease. Patch rest has been accepted as the only reliable diagnostic method to detect allergens. We analyzed patch test results of dermatologic outpatients and evaluated common new antigens producing cosmetic and noncosmetic contact dermatitis.
We reviewed patch test results of the 324 patients with suggestion contact dermatitis who had visited our department from May 1985 to February 1996. We divided the patients in two groups(cosmetic contact dermatitis group and non-cosmetic contact dermatitis group)and compared the results.
1) High positive reaction rate to nickel sulfate(14.7%), fragrance mix(11.0%), and mercury ammonium chloride(9.6%) was seen in cosmetic contact dermatitis group. Lip cosmetics and make-up preparation were the products to which patients reacted the most. Among the cosmetic products, skin care products ranked the first in positive reaction rate.
2) Nickel sulfate(21.7%) was the most common allergen, followed by cobalt chloride(13.3%), mercury ammonium chloride(10.0%), and fragrance mix(8.3%) in noncosmetic contact dermatitis.
Consmetic contact dermatitis was more common than noncosmetic contact dermatits. Nickel sulfate, mercury ammonium chloride, cobalt chloride and fragrance mix were found to be the most common allergens of cosmetic and noncosmetic contact dermatitis.
I compared the PCR assay using the
Fifty-seven out of 81(70%) patients were culture positive and 64 out of 81(79%) patients were PCR positive. In seventy-two out of 81 patients, PCR was concordant with culture, but 8 patients had only positive-PCR and one patient had only positive-culture. Diagnostic sensitivity, specificity, positive predictive value, negative predictive value and diagnostic efficiency of culture were 85%, 100%, 100%, 58% and 88%, respectively and those of PCR were 96%, 100%, 100%, 82% and 96%, respectively. The positive rates of
These findings suggest that the PCR assay using the ureC gene in gastric biopsy is more sensitive and rapid than culture and an effective test for the diagnosis of
Citations
, Hyun Joo Kim, Seung Lee Seo, Young Sook Kim, Mi Ae Lee, Jeong Hee Hahm Levofloxacin, an oral fluroquinolone antibacterial agent, is the optical S-(-) isomer of ofloxacin. In vitro it is generally twice as potent as ofloxacin and active against most aerobic gram positive and gram negative organisms, but only moderate activities against anaerobics.
Our purpose was to investigate the therapeutic efficacy and tolerability of levofloxacin in patients with several kinds of cutaneous infections.
Levofloxacin(CRAVIT®; Korea Daiich Parm. Co.) 300-600mg/day for 5-14days was administrated to eighteen patients with cutaneous and subcutaneous infections. The Bacterial culture and laboratory tests were performed prior to and after treatments. Clinical effects and adverse events were evaluated on laboratory indics.
1) Nine of thrteen cases(70%) were useful, four cases(30%) were slightly useful.
2) Clinically twelve of eighteen cases were cured and eight cases were partial response to the drug.
3) There were no laboratory abnormalities after levofloxacin treatment
4) Side effects were not significant except dizziness and sleep disturbance.
Levofloxacin was evaluated as a highly effective antibacterial agent against dermatologic infections.
Citations
, Ki Sook Hong In recent years, fungi have Played an increasingly important role as pathogens innosocomial infection, and the incidence of nosocomial fungemia appears to be increased as aresult of clinical and therapeutic factors. We investigated the incidence of fungemia and relationbetween the predisposing factors and fungal species to be helpful in the prevention and early diagnosis of nosocomial fungemia.
We reviewed 45 cases of fungemia in Ewha Womans University DongdaemoonHospital from Jan. 1991 to Oct. 1995 to examine the predisposing factors, underlying illness,concomitant bacteremia, morality and outcome by the fungal species.
During recent five years, fungemia was increased in incidence.
These results suggest that the incidence of fungemia are increased as a result ofvarious predisposing factors and removal of the predisposing factors will be helpful in the prevention of nosocomial fungemia.
Citations
, Ki Sook Hong Coagulase-negative staphylococci(CNS) once considered nonpathogenic contaminants, recently represent the leading organisms of hospital-acquire bacteremia in catheter-associated infections, immunocompromised patients and neonates. patients and neonates.
We reviewed 141 caews of CNS isolated from blood in Ehwa Womans University Dongdaemoon Hospital, from March 1993 to February 1994 and deagnosed as pathogens or contaminants by clinical data and performed species identification and antimicrobial susceptibility test.
The results were as follows:
1) 46.8% of isolated CNS from blood was diagnosed as pathogens and most common age of CNS bacteremia was less than 1 month(39.0%). The most frequent underlying desease was respiratory tract infection(28.1%) followed by neonatal desorder(17.2%), malignancy(12.5%) and urinary tract infection(6.3%).
2) The most common identified species of CNS bacteremia was
3) The antimicrobial susceptibility results of CNS bacteremia showed multi-drug resistance to penicillin(96.9%), cephalothin(75.0%), ampicillin/sulbactam(70.3%), oxacillin(70.3%), tetracycline(67.1%) and erythromycin(48.4%). But vancomycin resistance showed 1.6% of CNS bacteremia. Among CNS species,
These results that species identification and antimicrobial susceptibility test of CNS isolated from blood will be useful diagnostic tool of CNS bacteremia.
, Woon Sup Han, Ok Kyung Kim Endodermal sinus tumor is characterized by perivascular structures(Schiller-Duval bodies). which simulate endodermal diverticula of yolk sac origin. Endodermal sinus tumor has generally been reported to be in ovary and testis. Very few cases of endodermal sinus tumor originating from extragonadal sites such as mediastinum, pelvis, vagina, sacrococcygeal region, pineal gland have been described. The authors report a case of endodermal sinus tumor arising from pineal gland and briefly review literatures.
, So Yun Cho, Mi Ae Lee, Kyu Kwang Whang, Jeong Hee Hahm Angiolymphoid hyperplasia with eosinophilia(ALHE) is a benign, uncommon disorder of unknown etiology and usually appears as intradermal or subcutaneous, red to brown papules and/or nodules, usually located on the head and neck region, and occurring in young adults.
Histopathologically ALHE is an angiolymphoproliferative lesion which shows characteristically plump epitheloid or histioid endothelial cells, accompanied by an inflammatory infiltrate that mainly consists of lymphocytes and eosinophils.
We reported a case of angiolymphoid hypreplasia with eosinophilia occurring on the scalp in a 52-year-old female and review the literature.
, Mi Ae Lee, Hyung Chul Kang, Jeong Hee Hahm Xeroderma pigmentosum is a rare autosomal recessive disorder characterized by extreme photosensitivity and defect in repair of damage to DNA Lentigenes, freckles, telangiectasia and the hyperpigmented cutaneous macules in the sun-exposed area and early development of cutaneous malignancies are observed. In addition to cutaneous symptoms, ophthalmologic changes and neurologic abnormalities can be associated.
We report a case of xeroderma pigmentosum associated with squamous cell carcinoma in a 4-year-old girl. This case is thought to be more earlier development of malignancies than ever reported.
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