, Jin Hwa Lee, Sun Hee Sung, Seong Hoon Park Amiodarone has been widely used for supraventricular and ventricular arrhythmias and many patients benefit from its effectiveness in treating potentially life-threatening arrhythmias. However, this drug can cause multi-organ toxicity, including amiodarone-induced pulmonary toxicity (APT). Not only does amiodarone have a long half-life but also is lipophilic and therefore can easily accumulate in tissues. Hence, it is difficult to monitor therapeutic levels and side effects, making it difficult to predict toxicities. In this case, we describe multi-organ complications secondary to amiodarone use, especially APT combined with pneumonia with atypical pathogens and pulmonary hemorrhage. The patient reached a high cumulative dose of amiodarone despite a low maintenance dose of amiodarone. This case highlights an unusual presentation of APT with multi-organ toxicity and we review articles regarding the association between the cumulative dose of amiodarone and amiodarone-induced toxicities.
Citations
, Ho Seong Han, Young Woo Kim, Eu Gene Kim, Nam Jun Yi, Seong Hoon Park The number of the aged patient who undergo the operation has been increased in recent years. The risk of the operation is formidable in old patient. After general surgery, the morbidity and the mortality are associated with the pre-operative medical illness. And, the old age have more pre-operative medical illnesses than the younger. We experienced multiple postoperative complications in 85 years old patient. He has past history of old myocardiac infarction without other disease. He underwent the total gastrectomy with esophagojejunostomy due to advanced gastric cancer. After surgery, multiple post operative complications have occurred such as arrhythmia, hyponatremia, intraperitoneal abscess, gastrointestinal hemorrhage, pneumonia, heart failure, post operative delirium, phlebitis, hearing disturbance, nephropathy, would seroma, liver dysfunction, glucose intolerance. We summarized this case and give a brief review of the literature.
First
Prev
