The utilization of acetate & bicarbonate dialysate and their effects on acid-base balance, blood pressure, pulse rate, serum cholesterol, triglyceride, HDL and free fatty acid were investigated during regular hemodialysis.

Eight patients with chronic renal failure were studied during two successive dialysis treatments for which either acetate or bicarbonate were used as a buffer anion in the dialysate.

The result obtained as follows :

1) There was no significant difference in arterial pH between acetate and bicarbonate hemodialysis patients.

2) Arterial HCO₃ was higher significantly in patients with bicarbonate hemodialysis than acetate hemodialysis from 60 to 240 minutes (p<0.01)

3) Arterial pCO₂ fell significantly from 34.0 mmHg to 31.7 mmHg during acetate hemodialysis patient (p<0.01)

4) Heart rate rose signifificantly from 69 b.p.m to 82 b.p.m. during acetate hemodialysis(p<0.01).

5) Serum fatty acid increased significantly during acetate and bicarbonate hemodialysis, but no difference between two groups.

6) There were no significant changes in systolic and diastolic blood pressure in two groups during hemodialysis.

7) There were no significant changes in serum cholesterol, triglyceride and HDL in two groups during hemodialysis.