Experiences in the adjuvant chemotherapy with adriamycin on two cases of osteogenic sarcoma of the femur and tibia and one case of Ewing's sarcoma of the femur are presented.

The two cases of the osteogenic sarcoma were treated by a combination of radical amputation and chemotherapy.

One case of the Ewing's sarcoma was treated by the megavoltage radiotherapy and chemotherapy.

One patient with the osteosarcoma died of late pulmonary metastasis 13 months after the diagnosis and treatment, however, this patient had discontinued hie chemotherapy in three months. And also his initial amputation was delayed four months from initial diagnosis because of his hesitation.

Other two cases of osteogenic and Ewing's sarcoma are carrying on normal active daily life without local recurrance or pulmonary metastasis 11-17 months after the diagnosis of the osteogenic and Ewing's sarcoma respectively.

The observation and follow up period of our cases are too short to permit definite conclusions. However, preliminary results and the review of the literatures strongly support the possibility that adjuvant chemotherapy has improved the prognosis of the patients with the malignant bone tumors.