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Original Article

Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients

So Yeon Seo, JiSoo Lee, Eun-Suk Kang
The Ewha Medical Journal 2005;28(2):87-92. Published online: September 30, 2005

Department of Laboratory Medicine, College of Medicine, Ewha Womans University, Korea.

Copyright © 2005. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objectives
    To evaluate the clinical significances of antibodies to cyclic citrullinated peptides (anti-CCP) and IgM Rheumatoid Factor(RF) in patients with established rheumatoid arthritis.
  • Methods
    The subjects included 86 established RA patients according to the revised ACR criteria and 46 non-RA patients presenting joint manifestations and 61 healthy individuals as control. Anti-CCP and IgM RF were measured by ELISA and nephelometric method, respectively.
  • Results
    The sensitivity and specificity of anti-CCP were 64% and 98% and of IgM RF were 69% and 76%, respectively. Eleven (4 I %) out of 27 sero-negative RA patients had elevated anti-CCP. Combination of anti-CCP with IgM RF increased diagnostic sensitivity and specificity of RA to 81% and 99%, respectively.
  • Conclusion
    Simultaneous measurement of IgM RF and anti-CCP for the initial evaluation of arthritis would increase the diagnostic efficacy of RA.
  • Keywords: Rheumatoid arthritis; Anti-CCP antibodies; IgM rheumatoid factor

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      Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients
      Ihwa Ŭidae chi. 2005;28(2):87-92.   Published online September 30, 2005
      DOI: https://doi.org/10.12771/emj.2005.28.2.87
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
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      • Citation for the content below
      Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients
      Ihwa Ŭidae chi. 2005;28(2):87-92.   Published online September 30, 2005
      DOI: https://doi.org/10.12771/emj.2005.28.2.87
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      Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients
      Clinical Significance of Anti-Cyclic Citrullinated Peptide Antibodies and IgM Rheumatoid Factor in Rheumatoid Arthritis Patients
      Ewha Med J : The Ewha Medical Journal

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