Abstract

• An epidemiological study on the primary carcinoma of the liver was carried out to obtain further information on the causal factor of cholangiocarcinoma and hepatocellular carcinoma during the period of 1997 and 1978. Total 102 hospital records of the primary carcinoma of the liver from 3 Hospitals were collected and analysed. Among 102 primary carcinomas of the liver, cases of hepatocellular carcinoma and cholangiocarcinoma were 96 (M83, F13) and 6 (M6, F1) respectively and the ratio was 16.0 : 1. Total cases of the primary carcinoma of the liver combined with clonorchiasis were 18 (M16, F2). Prevalence rate was 17.6 Clonorchiasis cases combined with hepatocllular carcinoma and cholangiocarcinoma were 14 (M13, F1) and 4 (M3, F1). Prevalence rate (66.7%) in cholangiocarcinoma was much higher than that (14.6%) in hepatocellular carcinoma. The relative risk was 11.8. Average ages of total cases, hepatocellular carcinoma and cholangiocarcinoma cases were 51.9, 51.5 and 58.5 respectively. Ages of clonorchiasis cases combined with hepatocellular carcinoma were distributed from 30 throughout 60 and those combined with cholangiocarcinoma were limited in 50 and 60. From the epidemiological point of view, the evidence for a carcinogenic effect of Clonorchis infection is strongly suggestive.