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Case Report

Radiation Recall Dermatitis Induced by Gefitinib

Beodeul Kang, Ah Young Leem, Young Jae Kim, Eudong Hwang, Yujung Yun, Sun Wook Kim, Hyo Song Kim
The Ewha Medical Journal 2013;36(Suppl):S17-S21. Published online: December 23, 2013

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author: Hyo Song Kim. Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 50, Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2228-6661, Fax: 82-2-2227-7870, hyosong77@yuhs.ac
• Received: August 5, 2013   • Accepted: August 26, 2013

Copyright © 2013. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Radiation recall dermatitis refers to an acute inflammatory reaction in a previously irradiated field triggered by the administration of certain drugs days to years after the exposure to radiation. Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor and is an effective treatment for patients with advanced stage of non small cell lung cancer (NSCLC). Here, we report a rare case of gefitinib induced radiation recall dermatitis. A 52-year-old woman with a metastatic NSCLC had received a palliative radiation therapy of 20 cGy on spine metastasis area (C6-T6). After 24 days of receiving radiation therapy, she had started to take gefitinib. Eight months after taking drug, pain, swelling and erythema of skin were occurred on previously irradiated field. These symptoms were resolved after the cessation of gefitinib for 6 days and the topical use of steroid.
  • Keywords: Gefitinib; Lung cancer; Radiation recall dermatitis; Radiation therapy
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Fig. 1
(A) Erythema on upper back area (previously irradiated area). (B) Magnification of upper back area.
emj-36-S17-g001.jpg
Fig. 2
Skin thickening and localized edema of lower cervical and upper thoracic area. There are no definite evidence of cellulitis (gadolinium enhanced T1 weighted sagittal magnetic resonance imaging).
emj-36-S17-g002.jpg

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      Reactions Weekly.2014; 1490(1): 21.     CrossRef

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    Radiation Recall Dermatitis Induced by Gefitinib
    Ewha Med J. 2013;36(Suppl):S17-S21.   Published online December 23, 2013
    DOI: https://doi.org/10.12771/emj.2013.36.S.S17
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    Radiation Recall Dermatitis Induced by Gefitinib
    Ewha Med J. 2013;36(Suppl):S17-S21.   Published online December 23, 2013
    DOI: https://doi.org/10.12771/emj.2013.36.S.S17
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    Radiation Recall Dermatitis Induced by Gefitinib
    Image Image
    Fig. 1 (A) Erythema on upper back area (previously irradiated area). (B) Magnification of upper back area.
    Fig. 2 Skin thickening and localized edema of lower cervical and upper thoracic area. There are no definite evidence of cellulitis (gadolinium enhanced T1 weighted sagittal magnetic resonance imaging).

    Fig. 1

    Fig. 2

    Radiation Recall Dermatitis Induced by Gefitinib
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