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The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul

Mi Yeon Kim, Ki-Nam Shim, Hye-In Kim, Hyeon Ju Kang, Min Sun Ryu, So-Young Ahn, Hye Kyung Jung, Sung-Ae Jung
The Ewha Medical Journal 2014;37(1):26-29. Published online: March 25, 2014

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Ki-Nam Shim. Department of Internal Medicine, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 158-710, Korea. Tel: 82-2-2650-2632, Fax: 82-2655-2076, shimkn@ewha.ac.kr
• Received: August 30, 2013   • Accepted: October 11, 2013

Copyright © 2014. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objectives
    To investigate the rate of first-line eradication and the rate of second-line eradication of Helicobacter pylori (H. pylori) from 2001 to 2010 in a single institute in Seoul.
  • Methods
    Among the 2,717 patients who received H. pylori eradication treatment from 2001 to 2010 at Ewha Womans University Mokdong Hospital, the medical records of 1,466 patients who satisfied the condition of execution of upper gastrointestinal endoscopy, positive H. pylori eradication results at 6~8 weeks after eradication therapy were reviewed retrospectively. Then the first-line and second-line eradication rates and the eradication rates according to endoscopy findings were also compared.
  • Results
    The first-line eradication rate was 77% H. pylori eradication rate for the last 5 years was continuously increasing and no sign of decline was observed even for the whole 10 years. The rates of eradication related to endoscopic findings showed statistical significance (P<0.001) of 79.8% and 70.1% each for peptic ulcer and non-ulcerative gastric diseases, respectively.
  • Conclusion
    In this study, no decrease in tendency of first-line eradication rate could be found. In addition, the patients with the non-ulcerative gastric disease seemed to show significantly lower eradication rate. This finding suggests eradication treatment may be affected by the category of gastric diseases, and careful considerations should be taken assessing the effects and needs for the H. pylori eradication treatment.
  • Keywords: Helicobacter pylori; Eradication rate
  • 1. Seol SY. Treatment of Helicobacter pylori infection. Korean J Med 2006;70:349-351.
  • 2. Song HJ, Jung HC. Retreatment strategy of Hellcobacter pylori infection after initial treatment failure. Korean J Med 2003;65:272-276.
  • 3. Rokkas T, Sechopoulos P, Robotis I, Margantinis G, Pistiolas D. Cumulative H. pylori eradication rates in clinical practice by adopting first and second-line regimens proposed by the Maastricht III consensus and a third-line empirical regimen. Am J Gastroenterol 2009;104:21-25.
  • 4. Seo YH, Rhie SY, Park BJ, Kim HJ, Kim JG. Rescue therapies for Helicobacter pylori infection after failure of proton pump inhibitor-based standard triple therapy. Korean J Med 2008;74:23-29.
  • 5. Cheon JH, Kim N, Lee DH, Kim JW, Hwang JH, Park YS, et al. Trial of moxifloxacin-containing triple therapy after initial and second-line treatment failures for Helicobacter pylori infection. Korean J Gastroenterol 2005;45:111-117.
  • 6. Kim JH, Lee KT, Lee SM, Kim SH, Lee BS, Kim NJ, et al. Efficacy of ten days of clarithromycin, amoxicillin and omeprazole in eradicating Helicobacter pylori infection. Korean J Med 1999;56:581-589.
  • 7. Kim JI, Chung IS, Bhang CS, Park SH, Choi MG, Kim JK, et al. Factors influencing eradication of Helicobacter pylori in patients with peptic ulcer disease. Korean J Gastroenterol 1999;33:624-634.
  • 8. Park S, Cho SH, Choi KY, Chung IS, Chung KW, Sun HS, et al. Effect of single-dose vs. divided-dose drug administration on eradication of Helicobacter pylori in patients with peptic ulcers. Korean J Gastroenterol 2000;35:23-31.
  • 9. Song HJ, Yang YS, Lee IS, Lee KM, Lee DS, Kim SW, et al. Efficacy and tolerability of pantoprazole-based triple therapy in eradication of Helicobacter pylori in patients with peptic ulcer and/or gastritis. Korean J Gastroenterol 2000;36:185-191.
  • 10. Choi IJ, Jung HC, Choi KW, Kim JH, Ahn DS, Yang US, et al. Efficacy of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy forfor Helicobacter pylori Eradication. Korean J Gastroenterol 2001;37:336-344.
  • 11. Lee KM, Lee DS, Ahn BM, Song HJ, Kim SW, Han SW, et al. Effects of one - week triple therpy of ranitidine bismuth citrate, amoxicillin and clarithromycin in Helicobacter pylori-related peptic ulcer patients. Korean J Gastroenterol 2001;37:412-417.
  • 12. Graham DY, Lew GM, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, et al. Factors influencing the eradication of Helicobacter pylori with triple therapy. Gastroenterology 1992;102:493-496.
  • 13. Nam SW, Roe IH, Kim SB, Lee BS, Hwang YJ, Park HJ, et al. Detection of clarithromycin-resistant Helicobacter pylori by polymerase chain reaction. Korean J Gastroenterol 2000;36:450-456.
  • 14. Kim JJ, Reddy R, Lee M, Kim JG, El-Zaatari FA, Osato MS, et al. Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea. J Antimicrob Chemother 2001;47:459-461.
  • 15. Cho DK, Park SY, Kee WJ, Lee JH, Ki HS, Yoon KW, et al. The trend of eradication rate of Helicobacter pylori infection and clinical factors that affect the eradication of first-line therapy. Korean J Gastroenterol 2010;55:368-375.
  • 16. Kim JY, Kim N, Park HK, Jo HJ, Shin CM, Lee SH, et al. Primary antibiotic resistance of Helicobacter pylori strains and eradication rate according to gastroduodenal disease in korea. Korean J Gastroenterol 2011;58:74-81.
Fig. 1
First-line eradication rate of Helicobacter pylori (per protocol analysis).
emj-37-26-g001.jpg
Fig. 2
Second-line eradication rate of Helicobacter pylori (per protocol analysis).
emj-37-26-g002.jpg
Fig. 3
Eradication rates according to endoscopic findings (peptic ulcer disease vs. non-peptic ulcer disease).
emj-37-26-g003.jpg
Table 1
Characteristics and endoscopic findings of patients
emj-37-26-i001.jpg

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Eradication Rates of First-line and Second-line Therapy forHelicobacter pyloriInfection in Gyeongnam Province
      Gyo Hui Kim, Jin Ah Kim, Ui Won Ko, Jong Ho Park, Jue Yong Lee, Su Sin Jin, Yeon-Ho Joo, Jae Uk Shin
      The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2015; 15(3): 160.     CrossRef

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    The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul
    Ewha Med J. 2014;37(1):26-29.   Published online March 25, 2014
    DOI: https://doi.org/10.12771/emj.2014.37.1.26
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    The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul
    Ewha Med J. 2014;37(1):26-29.   Published online March 25, 2014
    DOI: https://doi.org/10.12771/emj.2014.37.1.26
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    The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul
    Image Image Image
    Fig. 1 First-line eradication rate of Helicobacter pylori (per protocol analysis).
    Fig. 2 Second-line eradication rate of Helicobacter pylori (per protocol analysis).
    Fig. 3 Eradication rates according to endoscopic findings (peptic ulcer disease vs. non-peptic ulcer disease).

    Fig. 1

    Fig. 2

    Fig. 3

    The Trend of First-Line and Second-Line Eradication Rates for Helicobacter pylori Infection in a Single Institute in Seoul

    Characteristics and endoscopic findings of patients
    Table 1 Characteristics and endoscopic findings of patients

    Table 1

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