Abstract

• The effects of cold temperature were studied nearly 300 years ago by Robert Boyle, who published a monograph entitled New Experiments & Observations Touching Cold. Since then numerous studies have been published on the subject of cryobiology. In recent years, detailed and comprehensive works about cryobiology and cryosurgery have been described by many investigators, among them Parkes, Rowbotham et al, Meryman, Hankinson, Smith, Von Leden and Cahan. This work for comparative studies on effects of skin cryodestruction was attempt to investigate a difference between Frigitronics and Walnuts instruments for the effects of skin cryodestruction.