Abstract

• With development of new technology such as handing technique and high resolution banding technique, cytogenetic examination has been utilized greatly in diagnosis and treatment of patients with hemato-oncologic diseases.
  Forty two patients with newly diagnosed and previously untreated hemato-oncologic diseases were examined for chromosomal abnormalities which included 11 cases of acute myelogenous leukemia(AML). 7 cases of acute lymphoblastic leukemia (ALL) and myelodyspalstic syndrome (MDS) each, 6 cases of chronic myelogenous leukemia (CML). 5 cases of other myelolproliferative disorders(MPD). 4 cases of non-Hodgkin's lymphoma(MHL). and 1 case each of aplastic anemia(AA) and malignant schwannoma(MS).
  Two cases of AML(18.2%) showed 45 XO and aneuploidy. Four cases of ALL(55.5%) showed chromosomal abnormalities : 3 cases with Philadelphia chromosome and 1 case with 45 XO.
  Only one case of MDS(14.3%) showed trisomy 8 and none of 3 cases which were converted to AML showed chromosomal abnormalities. Five cases of CML(83.3%) showed Philadelphia chromosome. Chromosomal abnormalities were not noted in cases of MPD, MHL, AA and MS.
  Collective studies of chromosomal abnormalities in hemato-onclologic diseases should be investigated further.