Abstract

• Objective
  To construct the neural network model in the striatum that can explain the clin-ical effect of Parkinson disease.
• Methods
  We use an approach to studying the function of neural systems that is based on the use of a class of computer models known as parallel distributed processors(PDPs).And the focus of this study is the nigrostriatal dopaminergic effects on the corticostriatal fibers and the striatal medium spiny neurons.
• Results
  A model that explains hypokinesia in Parkinson disease is presented for the opation of the striatum.
• Conclusions
  In order to study the brain funcion and mechanism of physiopathology, te-stable theories that consider brain as a whole system are needed. We think neural network model with PDPs would be an important field in neuroscience in near future.
• Keywords: Neural network; Parallel distributed processors; Parkinson disease