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Original Article

The Expression of bFGF m-RNA in the Gastric Cancer Tissues

Young-Woo Kim
The Ewha Medical Journal 1999;22(1):17-21. Published online: March 30, 1999

Department of Surgery, College of Medicine, Ewha Womans University, Korea.

Copyright © 1999. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Backgrounds
    The production of basic fibroblast growth factor(bFGF), which is known to have strong angiogenic activity in gastric cancer, was evaluated.
  • Methods
    Using Alkaline phosphoatase-labelled, synthetic oligonucleotide probe of bFGF genes, the expression of the gene was evaluated with in situ hybridization method in 9 fresh advanced gastric cancer tissues.
  • Results
    In situ Hybridization of bFGF mRNA showed positive reaction in 8 of 9 patients.
  • Conclusions
    In view of profuse expression of angiogenic growth factor, future therapeutic targeting for angiogenesis could be reasonable in patients with gastric cancer.
  • Keywords: Gastric cancer; Basic fibroblast growth factor; In situ hybridization; mRNA

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      The Expression of bFGF m-RNA in the Gastric Cancer Tissues
      Ihwa Ŭidae chi. 1999;22(1):17-21.   Published online March 30, 1999
      DOI: https://doi.org/10.12771/emj.1999.22.1.17
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      The Expression of bFGF m-RNA in the Gastric Cancer Tissues
      Ihwa Ŭidae chi. 1999;22(1):17-21.   Published online March 30, 1999
      DOI: https://doi.org/10.12771/emj.1999.22.1.17
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      The Expression of bFGF m-RNA in the Gastric Cancer Tissues
      The Expression of bFGF m-RNA in the Gastric Cancer Tissues
      Ewha Med J : The Ewha Medical Journal

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