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Original Article

Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women

Sa Ra Lee, Sung Eun Hur, Hye Sung Moon, Hyung-Lae Kim*, Hye Won Chung
The Ewha Medical Journal 2003;26(2):91-96. Published online: June 30, 2003

Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Center, Ewha Womans University, Korea.

*Department of Biochemistry, College of Medicine Ewha Medical Research Center, Ewha Womans University, Korea.

Copyright © 2003. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Objective
    To investigate whether polymorphism of gene encoding estrogen receptor-α is associated with the risk of endometriosis in Korean women.
  • Material and Methods
    We investigated 136 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-α genotype.
  • Results
    The distridution according to PvuII genetic polymorphism of estrogen receptor-α were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the control group, respectively. There was no significant difference between the study group and the control group.
  • Conclusion
    The results suggest that estrogen receptor-α genetic polymorphism may not be associated with the development of endometriosis in Korean women.
  • Keywords: Endometriosis; Genetic polymorphism; Estrogen receptor-α; PvuII

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      Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women
      Ihwa Ŭidae chi. 2003;26(2):91-96.   Published online June 30, 2003
      DOI: https://doi.org/10.12771/emj.2003.26.2.91
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      Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women
      Ihwa Ŭidae chi. 2003;26(2):91-96.   Published online June 30, 2003
      DOI: https://doi.org/10.12771/emj.2003.26.2.91
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      Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women
      Association of the Estrogen Receptor-α Gene Polymorphism with the Risk of Endometriosis in Korean Women
      Ewha Med J : The Ewha Medical Journal

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