No abstract available.

The effects of Naloxone, narcotic antagonist, pretreated with normal saline, salicylate and hydrocortisone produced by with hypovolemic shock on the rates of cytochrome components, mixed function oxidation enzyme reactions and lipid peroxidation have been determined using hepatic microsomal fractions of rats. The treatments with either of the naloxone have increased the contents of cytochrome P-450 and b_5 and NADPH- or NADH-cytochrome C reductase. But pretreated with salicylate and hydrocortisone were not change as compared to the control. The rates of O-demethylation for p-nitroanisole were decreased. Naloxone decreased the formation of lipid peroxide by pretreated salicylate and hydrocortisone. These results indicate that naloxone showed effect not only increase of blood pressure and respiration, but also cytochrome components activity, mixed function oxidation enzyme reactions and lipid peroxidation in the hepatic microsomal fractions of rats.

Proteoliposomes were prepared by reconstitution of a solubilized band 4.5 protein of human erythrocyte membrane with a mixture of phosphatidylcholine(PC) and phosphatidylethanolamine(PE) of varying ratios. The incorporation of the band 4.5 protein into the reconstituted vesicles was dependent on the stability of the bilayer of lipid added exogeneously when mixed soybean PE and egg PC were used for reconstitution. The protein/phospholipid ratio was maximal at 25% PC and 75%PE, the composition which give maximal bilayer instability. The specific activity of the cytochalasin B binding of the reconstituted band 4.5 protein increased monotonically as PC content increased in egg PC/soybean PE mixture. These coincide with the results of proteoliposomes reconstituted using crude protein extracts containing band 4.5 protein. Band 4.5 protein, however, changed significantly the phase of the lipid in reconstituted vesicles instead of that protein crude extract modified slightly the phase of the lipid. No lipidic particles (LIP, seen by freeze- fracture electron microscopy) were seen in all lipid mixtures studied. From above findings the fact that pre- existing defects in lipid bilayer promote protein incorporation into the bilayer during reconstitution is confirmed and band 4.5 protein somewhat seems to favor the bilayer structure.

The purpose of this study was to determine if differences could be found in hematologic and blood chemical assays of women with preeclampsia compared with normal pregnant controls. Seventy patients with severe preeclampsia, seventy with preeclampsia, and ninety normal pregnant women for control were taken part in this study at the Department of Obstetrics and Gynecology, Ewha Womans University Hospital from January, 1984 to March, 1986. The levels of hemoglobin, hematocrit, total bilirubin, alkaline phosphatase, serum glutamic oxaloacetic transaminase(SGOT), serum glutamic pyruvic transaminase(SGPT), total protein, albumin, blood urea nitrogen(BUN), creatinine, and uric acid in both of mild preeclampsia and severe preeclampsia group were measured and compared with those of normal pregnancy group. The results of this study were summarized as follows:1) The mean levels of hemoglobin, hematocrit, and platelets in both of mild preeclampsia and severe preeclampsia group were not significantly different from those of normal pregnancy group. 2) The mean total bilirubin levels in both of mild preeclampsia and severe preeclampsia group were not significantly different from that of normal pregnancy group. The mean level of alkaline phosphatase of mild preeclampsia group was significantly lower than of normal pregnancy group, but that of severe preeclampsia group was not significantly lower than that of normal pregnancy group. The mean SGOT level of mild preeclampsia group was not significantly higher than that of normal pregnancy group, but that of severe preeclampsia group was significantly higher than that of normal pregnancy group. The mean SGPT levels in both of mild preeclampsia and severe preeclampsia group were significantly increased than of normal pregnancy group. 3) The mean total protein levels in both of mild preeclampsia and severe preeclampsia group were significantly lower than that of normal pregnacy group. The mean serum albumin levels in both of mild preeclampsia and severe preeclampsia group were also significantly lower than of normal pregnancy group. The mean total protein and serum albumin level of sever preeclampsia group were significantly lower than those of mild preeclampsia group. 4) The mean BUN and serum creatinine level in both of mild preeclampsia and severe preeclampsia group were significantly higher than those of normal pregnancy group. The mean serum uric acid level of severe preeclampsia group was significantly increased than that of mild preeclampsia group.

Gold therapy is employed primarily in progressive rheumatoid arthritis which is refractory to the conventional measures such as aspirin-like agents. The benefical effects of gold therapy have been demonstrated by careful double blind trials on rheumatoid arthritis. However, its mechanism of action is poorly understood. A limitation to use the gold salt is its potential hazards and toxicity and great care should be given during gold therapy. This study was done to evaluate the effectiveness of gold salt on rheumatoid arthritis and its adverse effect during therapy. Forty-five rheumatoid arthritis patients who received gold sodium thiomalate at Ewha Womans University Hospital from. December 1983 to June 1985 were analyzed in this study. The results are as follows: 1) The incidence of rheumatoid arthritis was higher in female than in male with the ratio of 5:1 and the higher incidence was seen in the thirties and fourties(58%). 2) The mean duration of disease was 3.1 years, ranging 2 weeks to 11 years. 3) Common type of rheumatoid arthritis were the Classic and Definite type, and they were 18 cases(40%) and 15 cases(40%), respectively. The Probable(9 cases) and the Possible types(3 cases) were less common. 4) The average onset of clinical improvement was 12 weeks after gold therapy and the mean cumulative dose at this period was 550mg. 5) Thirty patients out of 45 patients showed marked to moderate clinical improvement after completion of gold therapy, whereas 12 patients did not respond. 3 patients were intolerated to gold therapy and discontinued due to severe adverse reactions. 6) The adverse reaction was observed in 32 of 45 patients receiving gold therapy for rheumatoid arthritis and the most common side reaction was dermatologic manifestations(21 cases). 7) There was no correlation between eosinophilia and the occurrance of the side effects.

Even with the conservative treatment, the humeral shaft fractures can be easily united with about 95% of union rate. According to Boyd(1961, 1965), the humeral shaft is the third of all the non-union of the shaft of long bones in the order of femur and tibia. From June 1978 to May 1985, 14 cases of non-union of humeral shaft were treated at Dept. of Orthopedic Surgery, Ewha University Hospital and the following results were obtained. 1) Of 14 cases, 8 were traffic accident and 4 were industrial injury. All were 20-40 age group and 13 cases were male. 2) The site was 9 cases of mid. 1/3, 3 cases of lower 1/3 and 2 of upper 1/3. The comminuted fracture was 12 cases and 2 cases were transverse. 3) The initial treatment after injury was 13 cases of operative methods; 9 cases were plate fixation; 3 cases, screw fixation; 1 case, intramedullary nailing. The other 1 case was conservative method. 4) The probable causes of non-union were complex. The most frequent one was inadequate internal fixation of 9 cases, 3 cases of inappropriate external immobilization and the other 2 were unknown. 5) 8 cases were treated with plate fixation, 2 cases with autogenous bone graft, 1 with EST(electric stimulation therapy) and 1 with intramedullary nailing. 6) Postoperative immobilization was done with long arm cast or shoulder spica cast. 7) All cases were united and the average union time was 9.1 weeks. Limitation of motion of shoulder and elbow was recovered with physiotherapy.

The clinico-statistical study was done on 147 cases of traumatic drum perforation who visited the Department of Otolaryngology, Ewha Womans University Hospital from Jan. '81 to Dec.' 85. Following results were obtained: 1) In sex incidence ; female incidence were more than male(ratio of female and male was about 1.3:1). In age distribution ; the highest incidence was in the group of 10's and 20's in male(70%) and in the group of 20's and 30's in female(75.2%). 2) The duration from tympanic membrane perforation to confirmation at E.N.T.O.P.D. was usually within 3 days in about 50%. 3) The main cause of drum perforation was direct trauma(70%). 4) Frequent complaints after trauma were hearing impairment(34.4%) and after ear stuffiness(18.9%) as in order. 5) The perforation was usually seen in the left ear(over 70% in male and female coincidentally). 6) Most frequent site of drum perforation was seen in anterior, central and posterior as in order. 7) Duration of the healing and hearing gaining after prosthesis was seen in 12 days and 9.7 dB in linear perforation, 14 days healing and 12 dB gaining in small perforation, 31 days healing and 12.6 dB gaining in medium sized perforation. In large perforation, the duration of the healing was mostly 55 days and hearing gaining was 17.2 dB after prosthesis.

Hydrocele, an abnormal accumulation of fluid between the parietal and visceral layers of the tunica vaginalis of the testis is the most frequently encountered mass of the scrotum. There are two types of treatment for hydrocele : Surgery and Sclerotherphy. Surgical treatment is generally considered the most effective. However, due to the frequent occurrence of complications of surgical procedure, sclerotheraphy may provide an alternative means of treatment. We here report the results of study using aspiration and subsequent injection of tetracycline as definitive treatment of testicular hydrocele. Four patients were treated after informed consent and followed for 5 to 10 months after sclerotheraphy. All treatment were given as an out-patient procedure. The aspiration were performed under local anesthesia, and the mean volume aspirated was 225ml(range : 150-350ml). Hereafter, 500mg of tetracycline diluted to a volume of 5ml in isotonic saline and 3ml in 2% lidocaine was injected. At 5 to 10 months follow up, all patients were cured-3 patients after one, and 1 patient after two injections. In one patient, the injection was immediately followed by scrotal pain which was relieved by spermatic cord block. The pain of the other patient were relieved by some oral analgesic medication. No infection or hematoma occured. In conclusion, aspiration and sclerotheraphy using tetracycline seems a favorable alternative to surgery for hydreceles. Tetracycline is both sclerosing, antibacterial and cheap. Further, the technique is simple, it carries a low morbidity and does not require hospitalization.