, Tae Hun Kim, Kum Hei Ryu, So Yeon Lim, Ju Ho Lee, Shi Nae Lee Hepatoid adenocarcinoma was described by Ishikura in 1985 for the first time. It is a very rare variant of adenocarcinoma characterized by morphological and functional features of hepatocyte differentiation. It is most commonly presented as gastric adenocarcinoma with otherwise unexplained elevation of serum alpha-fetoprotein level. Most of the patients with gastric hepatoid adenocarcinoma were diagnosed in advanced stages having vascular invasion and/or extensive metastasis in liver or lymph nodes. Accordingly, the prognosis of hepatoid adenocarcinoma is dismal. We experienced a typical case of gastric hepatoid adenocarcinoma and described the clinical features.
The purpose of this study was to evaluate MSI status in sporadic colorectal cancer and to correlate it with clinicopathologic variables.
Total 45 cases of surgically resected colorectal cancers retrospectively were reviewed about clinicopathologic findings and analyzed for micro satellite instability.
The microsatellite instability (MSI) was found in 5 of 45 cases (11.1%) . A significant association was found between MSI+ tumors and location in the right colon (40%), and high histological grade (100.0%), and mucinous phenotype (33.3%). There was no significant difference for age, sex, growth pattern, lymph node metastases, vessel invasion, or Duke's stage.
These data indicate that MSI frequently occur in colorectal cancers of the right side and in tumors with poorly differentiated or mucinous histology.
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