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Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea

Miae Lee
The Ewha Medical Journal 2016;39(2):37-44. Published online: April 29, 2016

Department of Laboratory Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Corresponding author: Miae Lee. Department of Laboratory Medicine, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea. Tel: 82-2-2650-5222, Fax: 82-2-2650-5091, miae@ewha.ac.kr
• Received: March 31, 2016   • Accepted: April 12, 2016

Copyright © 2016, The Ewha Medical Journal

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Despite recent advances in the development of diagnostics, therapeutics, and vaccines, the ease of international travel and increasing global interdependence have brought about particular challenges for the control of infectious diseases, highlighting concerns for the worldwide spread of emerging and reemerging infectious diseases. Korea is also facing public health challenges for controlling imported cases of infectious diseases; dengue virus, which is the most commonly reported case of imported infectious diseases; the largest outbreak of Middle East respiratory syndrome coronavirus infections outside the Arabian Peninsula in 2015; and the Zika virus infection, which was declared by the WHO as a "Public Health Emergency of International Concern." Although national and global partnerships are critical to controlling imported infectious disease threats, the role of local hospitals, public health sectors, and laboratory capacity remains the cornerstone for initial disease recognition and response. The current status of laboratory diagnosis for imported infectious diseases is reviewed.
  • Keywords: Emerging infectious diseases; Dengue; Middle East respiratory syndrome coronavirus; Zika virus; Diagnosis
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Fig. 1

Annual number of cases of dengue fever reported to the National Notifiable Diseases Surveillance System in Korea. Adapted from Korea Centers for Disease Control and Prevention [9].

emj-39-37-g001.jpg
Fig. 2

Proposed testing algorithm for suspected cases of arbovirus infection more than one week after onset of symptoms. Adapted from World Health Organization [44]. *Final interpretation of result should be done in conjunction with clinical presentation. †For paired serum samples, a four-fold rise in lgM in the absence of a rise in antibody titre to other flaviviruses is further evidence of recent Zika virus infection. ZIKV, Zika virus; DENV, Dengue virus; CHIK, Chikungunya virus.

emj-39-37-g002.jpg
Table 1

Interpretation of dengue diagnostic tests

Adapted from World Health Organization [18].

emj-39-37-i001.jpg

Figure & Data

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    Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea
    Ewha Med J. 2016;39(2):37-44.   Published online April 29, 2016
    DOI: https://doi.org/10.12771/emj.2016.39.2.37
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    Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea
    Ewha Med J. 2016;39(2):37-44.   Published online April 29, 2016
    DOI: https://doi.org/10.12771/emj.2016.39.2.37
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    Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea
    Image Image
    Fig. 1 Annual number of cases of dengue fever reported to the National Notifiable Diseases Surveillance System in Korea. Adapted from Korea Centers for Disease Control and Prevention [9].
    Fig. 2 Proposed testing algorithm for suspected cases of arbovirus infection more than one week after onset of symptoms. Adapted from World Health Organization [44]. *Final interpretation of result should be done in conjunction with clinical presentation. †For paired serum samples, a four-fold rise in lgM in the absence of a rise in antibody titre to other flaviviruses is further evidence of recent Zika virus infection. ZIKV, Zika virus; DENV, Dengue virus; CHIK, Chikungunya virus.

    Fig. 1

    Fig. 2

    Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea

    Interpretation of dengue diagnostic tests

    Adapted from World Health Organization [18].
    Table 1 Interpretation of dengue diagnostic tests

    Adapted from World Health Organization [18].

    Table 1

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