• Contact us
  • E-Submission

Ewha Med J : The Ewha Medical Journal

OPEN ACCESS
mobile search button mobile menu button
Search
Advanced Search
ABOUT
BROWSE ARTICLES
JOURNAL POLICIES
FOR CONTRIBUTORS

Articles

Page Path

Original Article

Change in Subfoveal Choroidal Thickness after Argon Laser Panretinal Photocoagulation

Ga Eun Cho, Ah Young Kim, Hee Yun Cho1, Yun Taek Kim
The Ewha Medical Journal 2017;40(2):71-76. Published online: April 28, 2017

Department of Ophthalmology, Ewha Womans University School of Medicine, Seoul, Korea.

1Department of Ophthalmology, Hanyang University School of Medicine, Seoul, Korea.

Corresponding author: Yun Taek Kim. Department of Ophthalmology, Ewha Womans University School of Medicine, 1071 Anyangcheon-ro, Yangcheon-gu, Seoul 07985, Korea. Tel: 82-2-2650-5153, Fax: 82-2-2654-4334, ytkim@ewha.ac.kr
• Received: March 25, 2017   • Accepted: April 18, 2017

Copyright © 2017. Ewha Womans University School of Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • 52 Views
  • 0 Download
  • 1 Crossref
prev next

Full Article

Download PDF Download PDF
  • Objectives
    To evaluate changes in subfoveal choroidal thickness (SFCT) and macular thickness as measured by enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) after argon laser panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy.
  • Methods
    This prospective, comparative case series included 21 patients (28 eyes) with severe diabetic retinopathy. All patients underwent three sessions of PRP. The SFCT and macular thickness were measured using EDI-OCT at baseline and one week after completion of 3 sessions of PRP.
  • Results
    SFCT before PRP was 318.1±96.5 µm and increased to 349.9±108.3 µm; P=0.001 after PRP. Macular thickness significantly increased at one week after PRP from 273.1±23.9 µm at baseline 295.8±25.3 µm at one week; (P<0.001). No significant relationship between the changes in macular thickness and SFCT was observed (r=−0.13, P=0.52).
  • Conclusion
    PRP induced increases in both SFCT and macular thickness. Changes in SFCT did not correlate with changes in macular thickness.
  • Keywords: Choroid; Diabetic retinopathy; Tomography, optical coherence; Macular edema; Photocoagulation
  • 1. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of Diabetic Retinopathy Study (DRS) findings, DRS Report Number 8. The Diabetic Retinopathy Study Research Group. Ophthalmology 1981;88:583-600.
  • 2. Ferris FL 3rd. Photocoagulation for diabetic retinopathy. Early Treatment Diabetic Retinopathy Study Research Group. JAMA 1991;266:1263-1265.
  • 3. Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991;98:5 Suppl. 766-785.
  • 4. Pahor D. Visual field loss after argon laser panretinal photocoagulation in diabetic retinopathy: full-versus mild-scatter coagulation. Int Ophthalmol 1998;22:313-319.
  • 5. Blondeau P, Pavan PR, Phelps CD. Acute pressure elevation following panretinal photocoagulation. Arch Ophthalmol 1981;99:1239-1241.
  • 6. Yuki T, Kimura Y, Nanbu S, Kishi S, Shimizu K. Ciliary body and choroidal detachment after laser photocoagulation for diabetic retinopathy: a high-frequency ultrasound study. Ophthalmology 1997;104:1259-1264.
  • 7. Lerner BC, Lakhanpal V, Schocket SS. Transient myopia and accommodative paresis following retinal cryotherapy and panretinal photocoagulation. Am J Ophthalmol 1984;97:704-708.
  • 8. Shimura M, Yasuda K, Nakazawa T, Abe T, Shiono T, Iida T, et al. Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2009;247:1617-1624.
  • 9. McDonald HR, Schatz H. Macular edema following panretinal photocoagulation. Retina 1985;5:5-10.
  • 10. Shimura M, Yasuda K, Nakazawa T, Kano T, Ohta S, Tamai M. Quantifying alterations of macular thickness before and after panretinal photocoagulation in patients with severe diabetic retinopathy and good vision. Ophthalmology 2003;110:2386-2394.
  • 11. Oh IK, Kim SW, Oh J, Lee TS, Huh K. Inflammatory and angiogenic factors in the aqueous humor and the relationship to diabetic retinopathy. Curr Eye Res 2010;35:1116-1127.
  • 12. Takahashi A, Nagaoka T, Sato E, Yoshida A. Effect of panretinal photocoagulation on choroidal circulation in the foveal region in patients with severe diabetic retinopathy. Br J Ophthalmol 2008;92:1369-1373.
  • 13. Margolis R, Spaide RF. A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol 2009;147:811-815.
  • 14. Torres VL, Brugnoni N, Kaiser PK, Singh AD. Optical coherence tomography enhanced depth imaging of choroidal tumors. Am J Ophthalmol 2011;151:586-593.e2.
  • 15. Maruko I, Iida T, Sugano Y, Ojima A, Ogasawara M, Spaide RF. Subfoveal choroidal thickness after treatment of central serous chorioretinopathy. Ophthalmology 2010;117:1792-1799.
  • 16. Fundus photographic risk factors for progression of diabetic retinopathy. ETDRS report number 12. Early Treatment Diabetic Retinopathy Study Research Group. Ophthalmology 1991;98:5 Suppl. 823-833.
  • 17. Early Treatment Diabetic Retinopathy Study design and baseline patient characteristics. ETDRS report number 7. Ophthalmology 1991;98:5 Suppl. 741-756.
  • 18. Techniques for scatter and local photocoagulation treatment of diabetic retinopathy: Early Treatment Diabetic Retinopathy Study Report no. 3. The Early Treatment Diabetic Retinopathy Study Research Group. Int Ophthalmol Clin 1987;27:254-264.
  • 19. Grover S, Murthy RK, Brar VS, Chalam KV. Normative data for macular thickness by high-definition spectral-domain optical coherence tomography (spectralis). Am J Ophthalmol 2009;148:266-271.
  • 20. Gentile RC, Stegman Z, Liebmann JM, Dayan AR, Tello C, Walsh JB, et al. Risk factors for ciliochoroidal effusion after panretinal photocoagulation. Ophthalmology 1996;103:827-832.
  • 21. Lee CJ, Smith JH, Kang-Mieler JJ, Budzynski E, Linsenmeier RA. Decreased circulation in the feline choriocapillaris underlying retinal photocoagulation lesions. Invest Ophthalmol Vis Sci 2011;52:3398-3403.
  • 22. Savage HI, Hendrix JW, Peterson DC, Young H, Wilkinson CP. Differences in pulsatile ocular blood flow among three classifications of diabetic retinopathy. Invest Ophthalmol Vis Sci 2004;45:4504-4509.
  • 23. Langham ME, Farrell RA, O'Brien V, Silver DM, Schilder P. Blood flow in the human eye. Acta Ophthalmol Suppl 1989;191:9-13.
  • 24. Lee SB, Yun YJ, Kim SH, Kim JY. Changes in macular thickness after panretinal photocoagulation in patients with severe diabetic retinopathy and no macular edema. Retina 2010;30:756-760.
  • 25. Nagaoka T, Kitaya N, Sugawara R, Yokota H, Mori F, Hikichi T, et al. Alteration of choroidal circulation in the foveal region in patients with type 2 diabetes. Br J Ophthalmol 2004;88:1060-1063.
  • 26. Berkowitz BA, Sato Y, Wilson CA, de Juan E. Blood-retinal barrier breakdown investigated by real-time magnetic resonance imaging after gadolinium-diethylenetriaminepentaacetic acid injection. Invest Ophthalmol Vis Sci 1991;32:2854-2860.
  • 27. Sen HA, Berkowitz BA, Ando N, de Juan E Jr. In vivo imaging of breakdown of the inner and outer blood-retinal barriers. Invest Ophthalmol Vis Sci 1992;33:3507-3512.
Fig. 1

Retinal images of a 47-year-old man with bilateral proliferative diabetic retinopathy. (A) Fundus photograph before panretinal photocoagulation shows no abnormalities on fovea centralis. (B,C) Enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) images of the left eye at baseline (B) and one week after completion of panretinal photocoagulation (C). Note that both subfoveal choroidal thickness and central subfield thickness increased from 322 µm to 360 µm and from 294 µm to 312 µm, respectively. Arrows indicate the site of measurement of choroidal thickness.

emj-40-71-g001.jpg
Fig. 2

Subfoveal choroidal thickness (SFCT) and central subfield thickness (CST) measurements at baseline and one week after panretinal photocoagulation (PRP). Optical coherence tomography revealed a statistically significant increase in SFCT and CST one week after PRP.

emj-40-71-g002.jpg
Fig. 3

Change of subfoveal choroidal thickness observed in individual subjects. PRP, panretinal photocoagulation.

emj-40-71-g003.jpg
Fig. 4

Scatter plot showing changes in subfoveal choroidal thickness (SFCT) and central subfield thickness (CST). A significant linear correlation between changes in SFCT and CST is not noted (r=-0.13, P=0.52).

emj-40-71-g004.jpg
Table 1

Demographic and clinical characteristics of patients

NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.

emj-40-71-i001.jpg
Table 2

Change in SFCT and CST

Note that both SFCT and CST increased significantly after PRP.

SFCT, subfoveal choroidal thickness; CST, central subfield thickness; PRP, panretinal photocoagulation; CI, confidence interval.

*Analysis performed by the paired-sample t-test.

emj-40-71-i002.jpg

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Choroidal Thickening Induced by Pioglitazone in Diabetic Patients
      Ju Seouk Lee, Chang Zoo Kim, Seung Uk Lee, Sang Joon Lee
      Korean Journal of Ophthalmology.2024; 38(5): 331.     CrossRef

    Download Citation

    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:

    Include:

    Change in Subfoveal Choroidal Thickness after Argon Laser Panretinal Photocoagulation
    Ewha Med J. 2017;40(2):71-76.   Published online April 28, 2017
    DOI: https://doi.org/10.12771/emj.2017.40.2.71
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Change in Subfoveal Choroidal Thickness after Argon Laser Panretinal Photocoagulation
    Ewha Med J. 2017;40(2):71-76.   Published online April 28, 2017
    DOI: https://doi.org/10.12771/emj.2017.40.2.71
    Close

    Figure

    • 0
    • 1
    • 2
    • 3
    Change in Subfoveal Choroidal Thickness after Argon Laser Panretinal Photocoagulation
    Image Image Image Image
    Fig. 1 Retinal images of a 47-year-old man with bilateral proliferative diabetic retinopathy. (A) Fundus photograph before panretinal photocoagulation shows no abnormalities on fovea centralis. (B,C) Enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) images of the left eye at baseline (B) and one week after completion of panretinal photocoagulation (C). Note that both subfoveal choroidal thickness and central subfield thickness increased from 322 µm to 360 µm and from 294 µm to 312 µm, respectively. Arrows indicate the site of measurement of choroidal thickness.
    Fig. 2 Subfoveal choroidal thickness (SFCT) and central subfield thickness (CST) measurements at baseline and one week after panretinal photocoagulation (PRP). Optical coherence tomography revealed a statistically significant increase in SFCT and CST one week after PRP.
    Fig. 3 Change of subfoveal choroidal thickness observed in individual subjects. PRP, panretinal photocoagulation.
    Fig. 4 Scatter plot showing changes in subfoveal choroidal thickness (SFCT) and central subfield thickness (CST). A significant linear correlation between changes in SFCT and CST is not noted (r=-0.13, P=0.52).

    Fig. 1

    Fig. 2

    Fig. 3

    Fig. 4

    Change in Subfoveal Choroidal Thickness after Argon Laser Panretinal Photocoagulation

    Demographic and clinical characteristics of patients

    NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.

    Change in SFCT and CST

    Note that both SFCT and CST increased significantly after PRP.

    SFCT, subfoveal choroidal thickness; CST, central subfield thickness; PRP, panretinal photocoagulation; CI, confidence interval.

    *Analysis performed by the paired-sample t-test.
    Table 1 Demographic and clinical characteristics of patients

    NPDR, nonproliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy.

    Table 2 Change in SFCT and CST

    Note that both SFCT and CST increased significantly after PRP.

    SFCT, subfoveal choroidal thickness; CST, central subfield thickness; PRP, panretinal photocoagulation; CI, confidence interval.

    *Analysis performed by the paired-sample t-test.

    Table 1

    Table 2

    Ewha Med J : The Ewha Medical Journal

    ABOUT

    BROWSE ARTICLES 

    JOURNAL POLICIES

    FOR CONTRIBUTORS 

    © Ewha Womans University College of Medicine.
    TOP