Abstract

• After menopause, the incidence of osteoporosis and cardiovascular is increased and the cause of both disease is estrogen deficiency. So we evaluated the relationship between serum lipid profile which is a good indicator of the cardiovascular disease and spinal bone mineral density. Spinal BMD was measured by dual photon absorptiometry and serum lipid profile and alkaline phosphatase, total calcium measured before initiating hormone replacement therapy. Z score was correlated with inversely with alkaline phosphatase(r=-0.35, p<0.05). Serum lipid level were divided into high and low risk category, after adjustment of risk category total cholesterol had significant affects on relationship with spinal Z score. Our results suggest that postmenopausal women with low Z score also have high total cholesterol should be cosidered as a special high risk group for prevention of cardioavascular disease.