• Contact us
  • E-Submission
ABOUT
BROWSE ARTICLES
JOURNAL POLICIES
FOR CONTRIBUTORS

Page Path

5
results for

"Model"

Filter

Article category

Keywords

Publication year

Authors

"Model"

Original article

[English]
Comparison of 3 guideline lipid emulsion regimens for local anesthetic systemic toxicity: an in silico study of bolus duration, total dose, and treatment delay in intravenous bupivacaine overdose
Sunho Lim, Sooyoung Cho, Eunbi Cho
Received September 23, 2026  Accepted October 23, 2026  Published online October 30, 2026  
DOI: https://doi.org/10.12771/emj.2026.01648    [Epub ahead of print]
Purpose
Lipid emulsion is the only specific antidote for local anesthetic systemic toxicity, but no dose-finding study has been conducted. We compared 3 published regimens and alternative schedules that deliver the same dose in different ways using a human model of intravenous bupivacaine overdose.
Methods
A 14-compartment human bupivacaine model was independently reimplemented without fitted parameters, replacing first-order lipid elimination with a saturable term. Toxicity was modeled as 112.5 mg administered intravenously over 3 minutes. Benefit was defined as the predicted maximum decrease in myocardial bupivacaine within 30 minutes, and harm as the predicted relative lipid load, indexed by peak plasma triglyceride concentration. Neither measure is a validated surrogate.
Results
The 3 guidelines specify the same doses but different bolus durations: 1 minute versus 2–3 minutes. At a matched dose of 12 mL/kg, myocardial bupivacaine decreased by 30.5% with the 1-minute bolus and 24.9% with the 2.5-minute bolus, with the same lipid load. The completed American Society of Regional Anesthesia and Pain Medicine regimen (7.64 mL/kg) achieved a 24.6% decrease versus 24.9% with 12 mL/kg; thus, complete regimens differ in schedule as well as dose. Repeating the 1-minute bolus twice, for a total of 4.5 mL/kg, achieved a 31.9% decrease with 62% less emulsion. Start time had the greatest effect: the best regimen achieved a 41.8% decrease when started at the end of the injection, but only 9.6% when started at 10 minutes.
Conclusion
In this bupivacaine model, bolus duration distinguished the regimens more than dose did, and delay had a greater effect than either, eliminating most of the benefit without changing the lipid load. Treatment should begin at the first signs of toxicity, and 20% lipid emulsion should be immediately available wherever local anesthetics are used.
  • 301 View
  • 26 Download

Original Articles

[English]
The use of the bicipital groove as an intraoperative landmark for proximal humeral rotation during fracture fixation
Hyun-Joo Lee, Sanghyun Joung, Erica Kholinne, Suk-Joong Lee, Jong Pil Yoon, Jun Tan, In-Ho Jeon
Ewha Med J 2024;47(2):e25.   Published online April 30, 2024
DOI: https://doi.org/10.12771/emj.2024.e25
Objectives:

This study aimed to quantify the relationship between proximal humeral rotation and the lateral border of the bicipital groove on fluoroscopic imaging.

Methods:

A composite normal humerus with a marker placed on the lateral border of the bicipital groove was affixed to a custom rotation device at the proximal cut segment. Consecutive fluoroscopic images were captured from −60° to 60° in 5° increments and from −15° to 15° in 1° increments. The index value was calculated by taking the ratio of the distance from the medial boundary of the proximal humerus to the lateral border of the bicipital groove to the distance between the medial and lateral boundaries of the proximal humerus. The correlation between the humeral rotation and the index value was determined.

Results:

The index value showed a strong positive linear correlation position during internal rotation of the humerus across the entire range (r=0.998, P<0.001), as well as when the humerus was externally rotated, ranging from 15° of internal rotation to 15° of external rotation (r=0.991, P<0.001).

Conclusion:

The lateral border of the bicipital groove may serve as a useful intraoperative landmark for assessing proximal humeral rotation. This could potentially enhance the outcomes of humeral fracture repair and upper arm arthroplasty.

Citations

Citations to this article as recorded by  
  • The Key Technologies and Technological Evolution Mechanisms of Robotic Systems for Fracture Reduction Surgery
    Shaolong Kuang, Xiaoyang Hu, Jianhua Li, Fang Wang, Xue Zhang, Lihai Zhang
    Advanced Intelligent Systems.2026;[Epub]     CrossRef
  • 7,368 View
  • 19 Download
  • 1 Web of Science
  • 1 Crossref
[English]

No abstract available in English.

  • 821 View
  • 0 Download
[English]
The Differences of Left Ventricular Geometry in Acute Myocardial Infarction and the Effects on Short Term Mortality
Kyung Jin Kim, In Sook Kang, Kihwan Kwon, Wook Bum Pyun, Gil Ja Shin
Ewha Med J 2013;36(1):26-34.   Published online March 25, 2013
DOI: https://doi.org/10.12771/emj.2013.36.1.26
Objectives

This study designed to find the differences of left ventricular (LV) geometry in acute myocardial infarction (AMI) between ST elevation myocardial infarction (STEMI) and non ST elevation myocardial infarction (NSTEMI) and the occurrences of adverse outcome according to the LV geometry.

Methods

Comprehensive echocardiographic analyses were performed in 256 patients with AMI. The left ventricular mass index (LVMI) and relative wall thickness (RWT) were calculated. LV geometry were classified into 4 groups based on RWT and LVMI: normal geometry (normal LVMI and normal RWT), concentric remodeling (normal LVMI and increased RWT), eccentric hypertrophy (increased LVMI and normal RWT), and concentric hypertrophy (increased LVMI and increased RWT). Cox proportional hazards models were used to evaluate the relationships among LV geometry and clinical outcomes.

Results

Patients with NSTEMI were more likely to have diabetes mellitus, hypertension, heart failure, stroke and previous myocardial infarction. By the geometric type, patients with NSTEMI were more likely to have eccentric hypertrophy (n=51, 34.7% vs. n=24, 22.0%, P=0.028). There was no significantly different adverse outcome between STEMI and NSTEMI patients. Fifteen patients (5.9%, 7 female [46.7%]) died and the median duration of survival was 10 days (range, 1 to 386 days). Concentric hypertrophy carried the greatest risk of all cause mortality (hazard ratios, 5.83; 95% confidence interval, 1.04 to 32.7).

Conclusion

NSTEMI patients had more likely to have eccentric hypertrophy but adverse outcome after AMI was not different between STEMI and NSTEMI patients. Concentric hypertrophy had the greatest risk of short term mortality.

  • 1,689 View
  • 2 Download
Case Report
[English]
Severe Negative Remodeling at the Middle Right Coronary Artery without Atheroma Plaque
Kyung Yoon Chang, Kyung Seon Park, Yoo A Choi, Ji Hee Kim, Bu Seok Jeon, Sung Ho Her
Ewha Med J 2012;35(1):65-68.   Published online March 31, 2012
DOI: https://doi.org/10.12771/emj.2012.35.1.65

Arterial remodeling is commonly observed in human atherosclerosis. It is a heterogeneous response ranging from positive remodeling to negative remodeling. Negative remodeling is a condition in which the vessel area decreases in size, often as a result of a structural change in the coronary vessel wall. But its contribution to myocardial ischemia in a de novo lesion has not been clearly shown. A 51-year-old female with exertional angina was admitted to our hospital. Coronary angiography was performed, revealing a severe stenosis at the middle part of the right coronary artery (RCA). Although we predilated ballooning at the middle RCA, the degree of stenosis did not improve. Thus intravascular ultrasound (IVUS) was performed. The lesion was not nearly showed plaque burden and severe negative remodeling. Though the cross-sectional narrowing percentage was significant, we decided to medical treatment for fearing coronary perforation by stenting. This case report intends to emphasize that severe coronary stenosis should be performed IVUS before the stenting. We describe a rare case with severe negative remodeling at the middle part of the RCA without atheroma plaque.

Citations

Citations to this article as recorded by  
  • Extreme negative remodeling of septal left anterior descending branch masquerading as a bifurcation lesion
    Ajith Ananthakrishna Pillai, Sasinthar Rangasamy
    The International Journal of Cardiovascular Imaging.2019; 35(4): 597.     CrossRef
  • 2,052 View
  • 2 Download
  • 1 Crossref
TOP