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"Eunhee Ha"

Editorial

[English]
Reflections on 25 hours a day at Ewha Womans University College of Medicine from August 2021 to January 2025: a dean’s farewell message
Eunhee Ha
Received February 14, 2025  Accepted February 23, 2025  Published online March 20, 2025  
DOI: https://doi.org/10.12771/emj.2025.00045    [Epub ahead of print]
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Original Article

[English]
Air pollution, including PM10, as a potential risk factor for the development of appendicitis in Korea: a case-crossover study
Yongho Jee, Jin Hoon Nam, Jongmin Oh, Gyoung Tae Noh, Eunhee Ha, Ryung Ah Lee
Ewha Med J 2024;47(3):e38.   Published online July 31, 2024
DOI: https://doi.org/10.12771/emj.2024.e38

Objectives: Interest in the association between particulate air pollution and appendicitis risk has been increasing in recent years, and previous studies have suggested a link between particulate matter ≤10 μm in diameter (PM10) and appendicitis. However, robust evidence is currently lacking. This study explored the association between short-term PM10 exposure and appendicitis using data from Ewha Womans University Mokdong Hospital, Seoul, Korea, between January 1, 2001 and December 31, 2018.

Methods: We employed a time-stratified case-crossover design using data from 6,526 appendicitis patients taken from the hospital’s electronic medical records system. We analyzed the data using a conditional logistic regression model adjusted for daily mean temperature and relative humidity. The effect size of PM10 was estimated in terms of each 10 μm/m3 increase in PM10 concentration. Sex, season, and age group were analyzed as subgroups.

Results: Appendicitis patients had been exposed to higher levels of PM10 concentrations 3 days (OR 1.045, 95% CI : 1.007–1.084) and 7 days (OR, 1.053; 95% CI, 1.005–1.103) before hospital admission. The case-crossover analysis stratified by sex, age, and season showed that the male sex, being aged under 10, and the cold season were associated with a significantly stronger association between appendicitis and PM10 concentrations.

Conclusion: Our study found that PM10 concentrations were associated with appendicitis in boys aged under 10. The cold season was also a risk factor. Further research with a larger sample size and with other pollutants is required to clarify the association between PM10 and appendicitis.

Citations

Citations to this article as recorded by  
  • Unresolved policy on the new placement of 2,000 entrants at Korean medical schools and this issue of Ewha Medical Journal
    Sun Huh
    The Ewha Medical Journal.2024;[Epub]     CrossRef
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  • 1 Web of Science
  • 1 Crossref

Review

[English]
Exposure to air pollution and precocious puberty: a systematic review
Rosie Lee, Jongmin Oh, Eunji Mun, Jung Eun Choi, Kyung Hee Kim, Ji Hyen Lee, Hae Soon Kim, Eunhee Ha
Ewha Med J 2024;47(2):e20.   Published online April 30, 2024
DOI: https://doi.org/10.12771/emj.2024.e20

The worldwide incidence of precocious puberty, which is associated with negative health outcomes, is increasing. Several studies have suggested that environmental factors contribute to the development of precocious puberty alongside genetic factors. Some epidemiological studies have provided limited evidence suggesting an association between exposure to air pollution and changes in pubertal development. This systematic review aimed to summarize existing evidence on the association between air pollution exposure and precocious puberty. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, we searched two databases (PubMed and Web of Science) until August 2023. The included studies assessed the association between air pollutant exposure and the risk of precocious puberty, early menarche, or pubertal development. Two authors independently performed study selection and data extraction. A meta-analysis and analysis of the risk of bias were infeasible due to the limited number of studies and the heterogeneity among them. The literature search resulted in 184 studies, from which we included six studies with sample sizes ranging from 437 to 4,074 participants. The studies reported heterogeneous outcomes. Four studies found that increased exposure to air pollution was related to earlier pubertal onset. One study was inconclusive, and another suggested that air pollutant exposure may delay the onset of thelarche. Most studies suggest that exposure to air pollutants accelerates pubertal development; however, the results from the available studies are inconsistent. More extensive and well-designed longitudinal studies are required for a comprehensive understanding of the association between air pollution and precocious puberty.

Citations

Citations to this article as recorded by  
  • Environmental factors trigger pubertal development
    Sofia Malave-Ortiz, Cameron Grant, Natalie D. Shaw
    Current Opinion in Pediatrics.2025;[Epub]     CrossRef
  • Gender equity in medicine, artificial intelligence, and other articles in this issue
    Sun Huh
    The Ewha Medical Journal.2024;[Epub]     CrossRef
  • 86 View
  • 2 Download
  • 2 Crossref

Original Article

[English]
A Proactive Testing Strategy to COVID-19 for Reopening University Campus during Omicron Wave in Korea: Ewha Safe Campus (ESC) Project
Whanhee Lee, Kyunghee Jung-Choi, Hyunjin Park, Seunghee Jun, Nackmoon Sung, Sun-Hwa Lee, Misun Chang, Hee Jung Choi, Chung-Jong Kim, Hyesook Park, Eunhee Ha
Ewha Med J 2023;46(3):e7.   Published online July 31, 2023
DOI: https://doi.org/10.12771/emj.2023.e7
ABSTRACT Objectives:

Ewha Womans University launched an on-campus Coronavirus disease-19 (COVID-19) response system called Ewha Safety Campus (ESC) Project in collaboration with the Seegene Inc. RT-PCR diagnostic tests for COVID-19 were proactively provided to the participants. This study examines the effectiveness of the on-campus testing strategy in controlling the reproduction number (Rt) and identifying student groups vulnerable to infection.

Methods:

The ESC project was launched on March 2, 2022, with a pilot period from Feb 22 to March 1, 2022—the peak of the Omicron variant wave. We collected daily data on the RT-PCR test results of the students of Ewha Womans University from Mar 2 to Apr 30, 2022. We daily calculated Rt and compared it with that of the general population of Korea (women, people aged 20–29 years, and Seoul residents). We also examined the students vulnerable to the infection based on the group-specific Rt and positivity rate.

Results:

A lower Rt was observed about 2 weeks after the implementation of the ESC Project than that of the general population. The lower Rt persisted during the entire study period. Dormitory residents had a higher Rt. The positivity rate was higher in students who did not comply with quarantine guidelines and did not receive the second dose of the vaccine.

Conclusion:

The study provides scientific evidence for the effectiveness of the on-campus testing strategy and different infection vulnerabilities of students, depending on dormitory residence, compliance with the quarantine guidelines, and vaccination.

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Perspective

[English]
The COVID-19 Pandemic Response System at University Level: The Case of Safe Campus Model at Ewha Womans University
Kyunghee Jung-Choi, Nackmoon Sung, Sun Hwa Lee, Misun Chang, Hee Jung Choi, Chung-Jong Kim, Nam-Kyong Choi, Hanna Kim, Yi-Jun Kim, Whanhee Lee, Hyesook Park, Eunhee Ha
Ewha Med J 2022;45(4):e18.   Published online October 31, 2022
DOI: https://doi.org/10.12771/emj.2022.e18
ABSTRACT

In response to the changes in the Coronavirus disease 2019 (COVID-19) epidemic situation, Ewha Womans University established Ewha Safe Campus (ESC), an on-campus infection outbreak management system, to allow students and faculty members to safely resume face-to face classes in 2022. The COVID-19 testing station, Ewha Safe Station, is the core element of ESC. Symptomatic students and faculty members perform a combo swab self-PCR test or receive a nasopharyngeal swab PCR test from experts to prevent the spread of COVID-19 through early detection and management. ESC is significant in that it detects infection risks and proactively implements preemptive measures in a university. The COVID-19 health response system model at the university level was applied for the first time in South Korea, reaching a milestone in the history of university health in South Korea. In particular, it is highly valuable that the test was free of charge, as it enabled all of the examinees to have easy access to the test through joint cooperation with the Seegene Medical Foundation. This is a successful example of cooperation between schools and private institutions for public health improvement. In the future, the direct and indirect effects of the establishment and implementation of ESC need to be evaluated and confirmed, and areas requiring improvements need to be identified in preparation for another infectious disease outbreak in the future.

Citations

Citations to this article as recorded by  
  • A Proactive Testing Strategy to COVID-19 for Reopening University Campus during Omicron Wave in Korea: Ewha Safe Campus (ESC) Project
    Whanhee Lee, Kyunghee Jung-Choi, Hyunjin Park, Seunghee Jun, Nackmoon Sung, Sun-Hwa Lee, Misun Chang, Hee Jung Choi, Chung-Jong Kim, Hyesook Park, Eunhee Ha
    The Ewha Medical Journal.2023;[Epub]     CrossRef
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  • 1 Web of Science
  • 1 Crossref

Original Article

[English]
Comparative Analysis of Health Patterns and Gaps due to Environmental Influences in South Korea and North Korea, 2000–2017
Yoorim Bang, Jongmin Oh, Eun Mee Kim, Ji Hyen Lee, Minah Kang, Miju Kim, Seok Hyang Kim, Jae Jin Han, Hae Soon Kim, Oran Kwon, Hunjoo Ha, Harris Hyun-soo Kim, Hye Won Chung, Eunshil Kim, Young Ju Kim, Yuri Kim, Younhee Kang, Eunhee Ha
Ewha Med J 2022;45(4):e14.   Published online October 31, 2022
DOI: https://doi.org/10.12771/emj.2022.e14
ABSTRACT Objectives:

To conduct a comparative study of children’s health in South Korea versus North Korea focusing on air pollution.

Methods:

We used annual mortality rate, prevalence, and environmental indicators data from the World Bank and World Health Organizations (WHO). Trend analysis of the two Koreas was conducted to evaluate changes in health status over time. Spearman’s correlation analysis was used to find out the correlation between environmental indicators and children’s health status.

Results:

We found a distinct gap in children’s health status between the two Koreas. While North Korea reported a higher death rate of children than South Korea, both showed a decreasing trend with the gap narrowing from 2000 to 2017. The prevalence of overweight and obesity increased and that of thinness decreased in both Koreas. Except PM2.5 exposure, South Korea reported higher figures in most indicators of air pollutant emissions (South Korea, mean (SD)=28.3 (2.0); North Korea, mean (SD)=36.5 (2.8), P-value=0.002).

Conclusion:

This study empirically discovered the gaps and patterns of children’s health between South Korea and North Korea. North Korean children experienced more severe health outcomes than children in South Korea. These findings imply that epigenetic modification caused by environmental stressors affect children’s health in the two Koreas despite similar genetic characteristics. Considering the gaps in children’s health between the two Koreas, more attention and resources need to be directed towards North Korea because the necessary commodities and services to improve children’s health are lacking in North Korea.

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Letters to the Editor

[English]
EMJ, A Research Platform for “Future Ready, Ewha Medicine”
Eunhee Ha
Ewha Med J 2022;45(3):e2.   Published online July 31, 2022
DOI: https://doi.org/10.12771/emj.2022.e2
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Review Article

[English]
Systematic Review on Sanitary Pads and Female Health
Jingang Woo, Soyeon Kim, Haesoon Kim, Kyoung Sook Jeong, EunMee Kim, Eunhee Ha
Ewha Med J 2019;42(3):25-38.   Published online July 31, 2019
DOI: https://doi.org/10.12771/emj.2019.42.3.25

The majority of South Korean females use sanitary pads, which contain various organic solvents which could be excreted before and during their menstruation. However, they are not provided with findings from studies about the health effects of sanitary pads. Therefore, this study aims to establish a list of potential health hazards of sanitary pads and address the need for further extensive research by pointing out the limitations of the previous literature. A systematic review was adopted to conduct quantitative and qualitative reviews based on the PRISMA (preferred reporting items for systematic reviews and meta-analyses). Studies from electronic databases such as PubMed, RISS, and Google Scholar were retrieved for the final analyses. In accordance with our findings, we proposed a set of limitations of the previous studies. A systematic review revealed that there were effects of sanitary pads on vaginal or vulvar skin, endometriosis, and vaginal microflora. The review also revealed that organic solvents, which sanitary pads are composed of, bring potential harmful effects on pregnancy, autoimmune disease, cardiovascular disease, and neurological development. Social environments such as hygiene use or puberty education also turned out to affect female health. It was inferred that a lack of non-occupational and domestic studies reflecting the distinguishing features of sanitary pads with a reliable sample size remains as an important limitation. This study suggests that organic solvents in sanitary pads may increase some health risks bringing reproductive, autoimmune, cardiovascular, and neurological effects. Due to a lack of studies, a more extensive study can contribute to the public health of South Korean females.

Citations

Citations to this article as recorded by  
  • Addressing the commercial determinants of menstrual health: a call to regulate menstrual product manufacturers
    Céline Brassart Olsen
    Health Promotion International.2024;[Epub]     CrossRef
  • The condition of women frequently changing sanitary pads in 28 cities of China: a cross-sectional study
    Jiachen Sun, Shuwen Bai, Qi Li, Meizhen Zhao, Lina Ge, Shuang Zang
    Reproductive Health.2024;[Epub]     CrossRef
  • Resource recovery from soiled sanitary napkin waste—a state-of-the-art review
    Muhammad Sajeed Abdul Hameed, Sreya Pacheeri Sreedharan, Purushothaman Sivapragasam, Samarshi Chakraborty, Chitra Devarajulu, Krishnasamy Sivagami
    Environmental Science and Pollution Research.2024; 31(21): 30336.     CrossRef
  • “Ritual Purity” Reimagined: Eco-Friendly Menstrual Practices and Emotional Well-being in Muslim Women
    Shahida
    Women's Reproductive Health.2024; 11(4): 767.     CrossRef
  • Impact of Hazardous Chemical compounds on Reproductive System Reported in Sanitary Products
    Mayuri K. Gaikwad, Mohini Upadhye, Dhanashri Borchate, Nilam Jankar
    Research Journal of Pharmacology and Pharmacodynamics.2023; : 112.     CrossRef
  • Menstrual cup webinar series: A developing model of modified pre- and post-tests in the online teaching-learning of primary health care workers
    Arti Gupta, Rajeev Aravindakshan, Vijayan Sharmila, Venkatashiva B Reddy, Yamini Marimuthu, Navya Krishna Naidu
    Journal of Education and Health Promotion.2023;[Epub]     CrossRef
  • A novel banana fiber pad for menstrual hygiene in India: a feasibility and acceptability study
    Krishnashree Achuthan, Sharanya Muthupalani, Vysakh Kani Kolil, Anju Bist, Krishna Sreesuthan, Aswathy Sreedevi
    BMC Women's Health.2021;[Epub]     CrossRef
  • Development and uncertainty estimation of cryogenic homogenization and static headspace–gas chromatography–mass spectrometry method for the simultaneous determination of twelve toxic volatiles in disposable menstrual products
    Minyeong Kim, Hye-Jin Park, Ok-Nam Bae, Seung-Hoon Baek
    Microchemical Journal.2020; 158: 105291.     CrossRef
  • 152 View
  • 5 Download
  • 5 Web of Science
  • 8 Crossref
Original Article
[English]
Sleep Quality, Depression, Social Support, and Susceptibility to Common Cold in Medical Students
Yoolwon Jeong, Jin Young Kim, Jae Sun Ryu, EunHee Ha, Hyesook Park
Ihwa Ŭidae chi 2009;32(2):65-70.   Published online September 30, 2009
DOI: https://doi.org/10.12771/emj.2009.32.2.65
Objectives

Although common cold is a major cause of morbidity among university students, studies on the risk factors in relation to physical, social, emotional life styles among university students are limited. We sought to evaluate the effects of life style, depressive symptoms, and social support in common cold among medical school students.

Methods

120 medical students were surveyed through a self-reported questionnaire. They were asked to rate the severity of eight respiratory symptoms of the Jackson Criterion during the previous month. The ratings were summed to calculate the total symptom score. Social support was assessed by using Interpersonal Support Evaluation List(ISEL). Depressive symptoms were assessed by using The Center for Epidemiologic studies Depression Scale(CES-D). A score of 16 or higher was used as the cut-off point for high depressive symptoms. Life style factors were also evaluated. that Wilcoxon rank sum test, Kruskal-Wallis test, Chi-square test, and logistic regression test were used.

Results

The symptom score ranged from 0 to 18 and the median was 10 among those who had experienced symptoms. 33(34.4%) had experienced cold during the last month. The social support score ranged from 91 to 156 and the median was 113. The prevalence of high depressive symptoms was 36.7%. Students with lower social support and higher depressive symptoms had higher cold symptom scores, although it was not statistically significant. Students who had evaluated their sleep quality and health status as bad had higher cold symptoms scores. In multiple logistics regression analysis, depression, sleep quality, and self-perceived health status were either significant or border-line significant risk factors of cold.

Conclusion

Our study suggests that life style factors such as sleep quality and self-perceived health status is associated with an increased susceptibility to common cold.

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