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Editorial

[English]
The spirit of Ewha, carried forward through devotion: an interview with Dr. Kumie Oh, alumna of the 27th graduating class, anesthesiologist
Nahyun Kwon, Jiyoon Kim
Received November 24, 2025  Accepted December 24, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.01018    [Epub ahead of print]
  • 14 View
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Opinion

[English]
Norovirus infection control in Korea: points to consider
Joowon Lee
Received November 24, 2025  Accepted December 31, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.01011    [Epub ahead of print]
  • 21 View
  • 0 Download

Case reports

[English]
Positional and ventilatory mechanics in the unexpected resolution of glycopyrrolate-induced tachycardia: a case report
Seung Ju Ahn, So Young Lee
Received November 5, 2025  Accepted December 24, 2025  Published online January 13, 2026  
DOI: https://doi.org/10.12771/emj.2025.00983    [Epub ahead of print]
A 28-year-old woman developed drug-induced tachycardia in the left lateral decubitus (LLD) position following intravenous administration of glycopyrrolate. The tachycardia was unresponsive to esmolol, labetalol, and fentanyl but resolved unexpectedly after the tidal volume was reduced from 8 to 6 mL/kg. Drug-induced tachycardia or arrhythmia occurring in the LLD position under mechanical ventilation may be attenuated by adopting a low tidal volume ventilation strategy (6 mL/kg).
  • 11 View
  • 0 Download
[English]
Raising awareness through a case of recurrent fractures in a child with congenital insensitivity to pain and anhidrosis in Saudi Arabia
Amaal Aldosari, Abdulraheem Almokhtar, Hashem Bukhary, Raed Sharaf, Khalid Alhomayani
Ewha Med J 2025;48(4):e64.   Published online October 28, 2025
DOI: https://doi.org/10.12771/emj.2025.00899
Patients with congenital insensitivity to pain and anhidrosis (CIPA) exhibit an inability to perceive pain, recurrent fractures, self-mutilation, and impaired thermoregulation, which lead to severe complications and high morbidity. Children with CIPA often sustain multiple unnoticed fractures that may be mistaken for child abuse because of the presence of fractures at different stages of healing. If unrecognized or inadequately managed, these injuries can cause permanent damage. We report the case of a 9-year-old boy who presented with recurrent fractures, chronic osteomyelitis, heterotrophic ossification, and gangrene. This case underscores the need for heightened awareness among healthcare providers regarding the clinical manifestations and management challenges of CIPA. It also emphasizes the importance of early diagnosis, meticulous follow-up, and a multidisciplinary approach to optimize outcomes and prevent severe complications in affected children.
  • 458 View
  • 23 Download

Review articles

[English]
Lifestyle prescriptions for obesity treatment in primary care: a narrative review
Ji-Hye Jung, YangIm Hur
Ewha Med J 2025;48(4):e54.   Published online October 27, 2025
DOI: https://doi.org/10.12771/emj.2025.00836
Purpose
This review aims to synthesize the most up-to-date evidence on effective lifestyle prescriptions for managing patients with obesity in the primary care setting.
Methods
A comprehensive literature search was conducted through June 2025 using major domestic and international databases, including PubMed, Google Scholar, and RISS, as well as the websites of relevant academic societies. The search strategy employed keywords such as “obesity,” “primary care,” “lifestyle intervention,” “diet,” “exercise,” and “behavioral therapy” in both English and Korean.
Results
Effective obesity management should be grounded in the new paradigm of adiposity-based chronic disease, which focuses on preventing and treating the medical complications associated with excessive fat accumulation. The essential components of a successful lifestyle prescription comprise 3 pillars: diet, exercise, and behavioral therapy. An individualized dietary plan that achieves an energy deficit of 500–750 kcal is fundamental. Exercise prescriptions should recommend a combination of aerobic and resistance training, along with strategies to minimize sedentary time. In behavioral therapy, high-intensity behavioral counseling, the 6A model (ask, assess, advise, agree, assist, arrange), self-monitoring, and cognitive-behavioral therapy techniques have all demonstrated efficacy.
Conclusion
Primary care physicians are not only capable but also uniquely positioned to lead long-term, patient-centered obesity management. Their comprehensive and integrative perspective makes them one of the most efficient and scalable resources in addressing the obesity epidemic.
  • 1,077 View
  • 39 Download
[English]
Lifestyle interventions for hypertension management in primary care: a narrative review
Byoungduck Han, Gyu Bae Lee, Jihyun Yoon, Yang-Hyun Kim
Ewha Med J 2025;48(4):e56.   Published online October 20, 2025
DOI: https://doi.org/10.12771/emj.2025.00850
Hypertension is one of the leading chronic diseases globally and a major contributor to cardiovascular morbidity and mortality. Despite advances in pharmacological therapy, medication alone remains limited in achieving optimal control. This review synthesizes recent hypertension management guidelines, including those from the European Society of Cardiology (ESC, 2024), American Heart Association/American College of Cardiology (AHA/ACC, 2025), Taiwan Society of Cardiology/Hypertension Society (2022), and Korean Society of Hypertension (KSH, 2018). All guidelines consistently emphasize sodium restriction, weight reduction, regular exercise, moderation of alcohol intake, smoking cessation, and adoption of healthy dietary patterns such as the Dietary Approaches to Stop Hypertension, Mediterranean, or culturally adapted diets. The ESC 2024 guideline elevates lifestyle modification to Class I, Level A, specifying targets for sodium (<2 g/day) and potassium (≥3.5 g/day). The AHA/ACC 2025 guideline provides quantitative estimates, reporting approximately 1/1 mm Hg blood pressure reduction per kilogram of weight loss, and incorporates newer strategies such as glucagon-like peptide-1 receptor agonists and bariatric surgery when lifestyle measures alone are insufficient. Taiwan’s 2022 guideline frames recommendations under the S-ABCDE (sodium restriction, alcohol limitation, body weight reduction, cigarette cessation, diet adaptation, exercise adoption) mnemonic and uniquely includes genetic factors such as ALDH2 polymorphisms. The KSH 2018 guideline emphasizes salt restriction (<6 g/day), maintaining a body mass index <25 kg/m2, and adherence to traditional Korean diets. Lifestyle modification remains the cornerstone of hypertension prevention and management, particularly in primary care. Future directions should focus on integrating these approaches with pharmacotherapy, digital health strategies, and personalized prescriptions.
  • 2,078 View
  • 44 Download
[English]
Aging with disability in polio survivors: a narrative review
Ju-Hee Hwang, Ga-Yang Shim
Ewha Med J 2025;48(4):e58.   Published online October 20, 2025
DOI: https://doi.org/10.12771/emj.2025.00843
This study aimed to provide a comprehensive understanding of aging with disability among polio survivors who continue to live with long-term sequelae. Although poliomyelitis has been eradicated in most regions, survivors entering older age face a dual challenge, as age-related decline overlaps with pre-existing impairments, creating a need for integrated management strategies. This narrative review examined the epidemiology, clinical manifestations, and late effects of polio, with particular attention to post-polio syndrome, secondary musculoskeletal disorders, and other systemic conditions. International and Korean studies were compared to highlight similarities and contextual differences. Polio survivors frequently experience accelerated functional decline due to post-polio syndrome, fatigue, pain, musculoskeletal disorders (e.g., arthritis, osteoporosis, fractures), and cardiopulmonary dysfunction. Approximately 64% report major falls, with 35% sustaining fractures, often at vulnerable sites such as the hip or distal femur. Psychological distress, sleep disturbances, metabolic syndrome, and cardiovascular disease are also prevalent, further compounding frailty. In Korea, where most survivors are now over 60 years of age, epidemiological patterns differ from those of Western cohorts; however, systematic investigations remain limited. Polio survivors exemplify the dual burden of aging and long-term disability, underscoring the need to move beyond fragmented, symptom-focused care toward integrated, life course–oriented approaches. Anticipating and managing late effects, strengthening preventive strategies, and ensuring equitable healthcare access are essential for maintaining function, independence, and quality of life. Lessons drawn from polio survivors offer valuable insights for understanding aging with disability more broadly.
  • 1,561 View
  • 47 Download
[English]
Fragility fractures, particularly hip fractures, represent a major public health concern among older adults and are associated with high morbidity, mortality, functional decline, and socioeconomic burden. Cognitive impairment is common in older adults with hip fractures and contributes to increased fracture risk, poor postoperative outcomes, delayed recovery, and higher rates of institutionalization. This review aimed to examine rehabilitation strategies for older adults with hip fractures, with a specific focus on considerations for those with cognitive impairment. Evidence suggests that individuals with mild-to-moderate cognitive impairment can achieve meaningful functional gains through structured, intensive, multidisciplinary rehabilitation programs incorporating progressive resistance training, balance and mobility exercises, and individualized approaches tailored to cognitive and physical abilities. However, the implementation of such programs is often hindered by insufficient staff training and awareness in dementia-specific rehabilitation, limited resources, and the lack of standardized protocols defining eligibility, intensity, and adaptation. Optimizing outcomes requires structured, tailored rehabilitation protocols, enhanced staff education, interprofessional collaboration, and proactive management of delirium and secondary fracture prevention through fracture liaison services, while concurrently addressing systemic barriers such as resource constraints. Integrated, coordinated care across the continuum is essential to maximize recovery, independence, and quality of life in older adults with hip fractures and cognitive impairment.
  • 1,771 View
  • 31 Download
[English]
Not just small adults–practical pearls in pediatric anesthesia: a narrative review
Hee Young Kim
Ewha Med J 2025;48(4):e63.   Published online October 20, 2025
DOI: https://doi.org/10.12771/emj.2025.00766
Pediatric anesthesia presents unique challenges due to children’s distinct physiological and anatomical characteristics, including variations in drug metabolism, airway structure, and respiratory and circulatory regulation. Despite significant advances in patient safety that have reduced anesthesia-related mortality over recent decades, the declining pediatric population has made specialized training and clinical practice increasingly difficult. This narrative review addresses practical aspects of pediatric anesthesia, emphasizing patient monitoring, airway management, and recent clinical advances. Oxygen supply targets in children require careful titration to ensure adequate tissue oxygenation while avoiding oxygen toxicity and its associated complications, such as bronchopulmonary dysplasia and retinopathy of prematurity. Quantitative monitoring of neuromuscular blockade, such as with train-of-four stimulation, is essential to prevent postoperative respiratory complications. Temperature monitoring is equally critical in pediatric surgery because children and neonates are highly susceptible to intraoperative hypothermia. Airway management in infants and young children is complicated by anatomical differences, and while video laryngoscopy offers advantages, evidence for its benefits in neonates remains inconclusive. Extubation strategies must be individualized, taking into account risks such as laryngospasm and airway obstruction, as both deep and awake extubation have demonstrated comparable safety profiles. Emerging modalities, such as transfontanelle ultrasonography, provide real-time cerebral blood flow assessment and enhance perioperative brain monitoring. Regional anesthesia techniques in neonates and infants reduce exposure to general anesthetics and facilitate faster recovery but require meticulous technique and monitoring to ensure safety. Multidisciplinary collaboration and effective communication with parents are essential to achieving optimal outcomes.
  • 624 View
  • 24 Download
[English]
Core principles and structures of geriatric rehabilitation: a narrative review
Jae-Young Lim
Ewha Med J 2025;48(4):e57.   Published online October 14, 2025
DOI: https://doi.org/10.12771/emj.2025.00829
Globally, rapid population aging—particularly in Korea—has extended life expectancy but not proportionally extended healthy life expectancy, resulting in longer periods of illness or disability and a higher demand for complex medical and social care. Therefore, prolonging healthy life and improving health-related quality of life have become primary objectives in geriatric medicine and rehabilitation. Geriatric rehabilitation is a critical intervention aimed at optimizing the functioning of older adults and pre-morbidly frail individuals who have lost independence due to acute illness or injury. For many older patients, the goal shifts from complete recovery to achieving a new equilibrium, maximizing autonomy despite greater dependency. Geriatric rehabilitation also targets key geriatric syndromes such as frailty, recognizing it as a dynamic and potentially reversible state that provides a crucial “time window” for intervention. This review summarizes the core principles and structural elements essential for geriatric rehabilitation, emphasizing the implementation challenges within the Korean healthcare system. Unlike the European consensus, which supports structured inpatient and outpatient services with seamless transitions of care guided by Comprehensive Geriatric Assessment, the Korean healthcare system remains fragmented and heavily centered on acute hospitals. This highlights the urgent need for a systematic model to integrate care facilities and strengthen interprofessional collaboration to support community-based “aging in place.” Effective geriatric rehabilitation requires multidisciplinary teams and multifaceted approaches to optimize quality of life, social participation, and independent living. Despite its importance, substantial awareness gaps and policy barriers persist, underscoring an urgent call to action.
  • 1,053 View
  • 40 Download
[English]
Lifestyle prescriptions for diabetes management in primary care: a narrative review
Hye Jun Lee, Jung-Ha Kim
Ewha Med J 2025;48(4):e55.   Published online October 14, 2025
DOI: https://doi.org/10.12771/emj.2025.00808
Diabetes mellitus is a complex chronic disease with a rapidly increasing global prevalence. For this condition, non-pharmacological lifestyle modification is as important as pharmacological treatment. This review aims to comprehensively examine lifestyle prescriptions for diabetes across multiple domains to integrate current insights and understanding. In medical nutrition therapy, which is central to diabetes treatment and management, excessive carbohydrate intake should be restricted, while individualized consumption of high-quality carbohydrates, protein, and unsaturated fatty acids is recommended. Intake of added sugars and sodium should also be limited. Physical activity should similarly be tailored to the individual, with a combination of aerobic exercise and resistance training recommended. Careful consideration of hypoglycemia risk and diabetes complications is essential. Additional strategies include limitations on uninterrupted sedentary time to less than 30 minutes, maintenance of a healthy body weight, smoking cessation, alcohol abstinence, sleep health improvements, and attention to psychosocial care. In primary care settings, patient-specific assessment, multidisciplinary lifestyle prescriptions, and education to support behavior modification are expected to play a pivotal role in the treatment and management of diabetes.
  • 648 View
  • 34 Download
[English]
South Korea is experiencing a rapid demographic transition, with the proportion of older adults projected to exceed 20% by 2025. This unprecedented pace has intensified the demand for healthcare and social support, creating complex challenges in the management of multimorbidity, frailty, and functional dependency. Historically, Korea has relied on a rigid, provider-centered model, with healthcare financed through National Health Insurance and long-term care through long-term care insurance. Although these systems expanded service availability, they also entrenched fragmentation between long-term care hospitals and nursing homes. Recent reforms mark a paradigm shift toward person-centered, integrated care. The Community Care pilot programs (2019–2022) and the Integrated Community Care Support Act (2024) introduced coordinated models that link healthcare, housing, and social services under local government leadership. Evidence from domestic and international studies underscores the risks of prolonged institutionalization and highlights the benefits of integrated approaches, including reduced hospitalizations, improved functional independence, and higher satisfaction among older adults and their families. At the same time, experiences from Korea and Japan suggest that institutional care remains indispensable for individuals with high medical needs or at the end of life, emphasizing the need for balanced strategies. Successful implementation of the 2026 reforms will require redefining the role of institutions, expanding community-based alternatives, developing a professional care manager workforce, achieving interoperability of data systems, and undertaking financing reforms to align incentives. Beyond structural change, embedding a cultural ethos that values dignity, autonomy, and personhood will be essential. Korea’s evolving model not only responds to urgent demographic challenges but also offers lessons for other aging societies.
  • 2,823 View
  • 19 Download
[English]
Generative artificial intelligence (GenAI), including large language models such as GPT-4 and image-generation tools like DALL-E, is rapidly transforming the landscape of medical education. These technologies present promising opportunities for advancing personalized learning, clinical simulation, assessment, curriculum development, and academic writing. Medical schools have begun incorporating GenAI tools to support students’ self-directed study, design virtual patient encounters, automate formative feedback, and streamline content creation. Preliminary evidence suggests improvements in engagement, efficiency, and scalability. However, GenAI integration also introduces substantial challenges. Key concerns include hallucinated or inaccurate content, bias and inequity in artificial intelligence (AI)-generated materials, ethical issues related to plagiarism and authorship, risks to academic integrity, and the potential erosion of empathy and humanistic values in training. Furthermore, most institutions currently lack formal policies, structured training, and clear guidelines for responsible GenAI use. To realize the full potential of GenAI in medical education, educators must adopt a balanced approach that prioritizes accuracy, equity, transparency, and human oversight. Faculty development, AI literacy among learners, ethical frameworks, and investment in infrastructure are essential for sustainable adoption. As the role of AI in medicine expands, medical education must evolve in parallel to prepare future physicians who are not only skilled users of advanced technologies but also compassionate, reflective practitioners.

Citations

Citations to this article as recorded by  
  • Using virtual reality to support the transition from preclinical to clinical training in paediatric dentistry
    Marion Lautier, Faustine Béal, Amélie Reibel Domergue, Sophie Jung, François Clauss, Marion Strub
    BMC Medical Education.2026;[Epub]     CrossRef
  • 1,753 View
  • 98 Download
  • 1 Crossref
[English]
Personalized perioperative pain management: a narrative review
Min Kyoung Kim, Hyun Kang
Ewha Med J 2025;48(4):e62.   Published online September 16, 2025
DOI: https://doi.org/10.12771/emj.2025.00773
Perioperative pain management has shifted from standardized, procedure-based protocols toward individualized, patient-centered approaches. Inadequate pain control can result in short-term adverse outcomes, including delayed ambulation, prolonged hospitalization, and increased complications, as well as long-term sequelae such as chronic persistent postsurgical pain. Early models of preemptive and preventive analgesia emphasized pain relief primarily through the use of opioids. Growing concern about opioid-related adverse effects established the basis for multimodal and opioid-sparing strategies. Nevertheless, with the onset of the global opioid crisis, heightened awareness of the risks of opioid overuse has fueled interest in opioid-free techniques. However, evidence does not demonstrate that opioid-free methods are superior to opioid-sparing approaches. This underscores the importance of returning to the central goals of enhanced recovery after surgery: early restoration of function and reduction of complications. Within this framework, personalized pain management has emerged as a practical paradigm that tailors interventions to individual characteristics, including comorbidities, psychological status, pain sensitivity, and recovery objectives. This review outlines the rationale, current practices, and future directions of personalized perioperative pain management and proposes a framework for integrating new strategies into clinical care.
  • 1,187 View
  • 40 Download
[English]
Two paths, one goal–uniting regional and general anesthesia for optimal surgical care: a narrative review
Min Kyoung Kim, Oh Haeng Lee, Hyun Kang
Ewha Med J 2025;48(4):e61.   Published online September 16, 2025
DOI: https://doi.org/10.12771/emj.2025.00724
The integration of regional anesthesia (RA) with general anesthesia (GA) has become a central component of multimodal strategies to improve perioperative pain management. This approach not only enhances analgesic efficacy but also reduces opioid requirements and mitigates opioid-related adverse effects. By targeting peripheral or neuraxial nociceptive pathways, RA attenuates the surgical stress response and decreases central sensitization, complementing the systemic actions of GA. The combined application of RA and GA has shown substantial benefits across a wide range of surgical procedures, including abdominal, thoracic, orthopedic, and pediatric operations. Reported advantages include improved hemodynamic stability, enhanced pulmonary function, earlier ambulation, faster gastrointestinal recovery, and greater patient satisfaction. Moreover, recent evidence indicates a positive association between effective postoperative pain control and long-term outcomes, such as reduced incidence of persistent postsurgical pain, better functional independence, and even improved immune function and survival following cancer surgery. The development of sustained-release local anesthetic delivery systems, which provide localized and prolonged analgesia, further extends the benefits of RA-GA integration into the postoperative period. This review summarizes the mechanistic rationale, clinical applications, and future directions of RA-GA combinations in modern surgical care, with special emphasis on their role in enhanced recovery after surgery protocols.
  • 2,087 View
  • 29 Download
[English]
Non‑operative management, particularly the watch and wait (WW) strategy, has emerged as an alternative to total mesorectal excision for selected patients with locally advanced rectal cancer who achieve a clinical complete response (cCR) after neoadjuvant treatment. This narrative review examines oncologic outcomes, functional and quality‑of‑life benefits, diagnostic challenges, and surveillance requirements associated with WW compared to radical surgery. Evidence from randomized trials and international registries indicates that WW provides overall and disease-free survival rates comparable to those of surgery, provided that stringent selection criteria and intensive surveillance are maintained for 3 to 5 years. Local regrowth occurs in 15%–40% of patients—most commonly within 24 months—but salvage surgery is curative in over 90% of cases and restores oncologic equivalence. Nevertheless, distant metastasis is more frequent in patients who experience regrowth, underscoring the importance of early detection and the need for optimized systemic therapy. Accurate determination of cCR remains the primary limitation; digital rectal examination, high‑resolution magnetic resonance imaging, and endoscopy, even when combined, cannot reliably exclude microscopic residual disease. Total neoadjuvant therapy increases cCR rates to 30%–60% and expands the pool of WW candidates, but also intensifies the need for standardized response definitions and surveillance algorithms. WW offers organ preservation and quality‑of‑life improvements without compromising survival in carefully selected patients, provided that multidisciplinary teams ensure rigorous response assessment and lifelong monitoring. Future advances in imaging, molecular biomarkers, and individualized risk stratification are expected to further enhance the safety of WW and expand eligibility to a broader patient population.
  • 2,810 View
  • 52 Download

Health statistics

[English]
Cause of death statistics in 2022 in the Republic of Korea
Jung-Hyun Oh, Juhee Seo, Hyun Jung Park
Ewha Med J 2025;48(3):e46.   Published online July 28, 2025
DOI: https://doi.org/10.12771/emj.2025.00689
Purpose
This study aimed to describe mortality trends in the Republic of Korea in 2022 by analyzing total deaths, crude and age-standardized mortality rates, as well as age- and sex-specific patterns and changes in cause-specific mortality. The analysis updates previous reports with newly available data from 2022.
Methods
A repeated cross-sectional analysis was performed using nationwide death certificate data collected through municipal administrative offices. Deaths occurring in 2022 were aggregated from reports filed over a 16-month period, spanning January 2022 to April 2023. Causes of death were classified according to the World Health Organization’s International Classification of Diseases. Quality assurance was ensured through administrative record linkage across 22 databases and validation using an independent infant mortality survey. Descriptive statistics were employed to summarize the findings.
Results
In 2022, Korea recorded 372,939 deaths (the highest annual total since 1983), corresponding to a crude death rate of 727.6 per 100,000 population. This increase contributed to a net population decline of 123,751. Mortality rates rose across most age groups, with particularly marked increases among those aged 1–9 and those aged 80 or older. Coronavirus disease 2019 (COVID-19) became the third leading cause of death (31,280 deaths; 61.0 per 100,000), driven largely by the Omicron variant and heightened infection rates among older adults. Pancreatic cancer overtook stomach cancer in the mortality rankings. There were sharp increases in deaths attributed to Alzheimer’s disease and diabetes. Although deaths from intentional self-harm declined, suicide remained a significant cause of death among younger individuals.
Conclusion
Korea experienced a record-high mortality rate in 2022, largely due to the impacts of COVID-19 and ongoing population aging. Notable shifts in cause-specific mortality were observed, including increases in deaths from Alzheimer’s disease, diabetes, and pancreatic cancer, underscoring evolving public health challenges.
  • 16,453 View
  • 57 Download

Original articles

[English]
Purpose
This study evaluated the feasibility and performance of a deep learning approach utilizing the Korean Medical BERT (KM-BERT) model for the automated classification of underlying causes of death within national mortality statistics. It aimed to assess predictive accuracy throughout the cause-of-death coding workflow and to identify limitations and opportunities for further artificial intelligence (AI) integration.
Methods
We performed a retrospective prediction study using 693,587 death certificates issued in Korea between January 2021 and December 2022. Free-text fields for immediate, antecedent, and contributory causes were concatenated and fine-tuned with KM-BERT. Three classification models were developed: (1) final underlying cause prediction (International Classification of Diseases, 10th Revision [ICD-10] code) from certificate inputs, (2) tentative underlying cause selection based on ICD-10 Volume 2 rules, and (3) classification of individual cause-of-death entries. Models were trained and validated using 2021 data (80% training, 20% validation) and evaluated on 2022 data. Performance metrics included overall accuracy, weighted F1 score, and macro F1 score.
Results
On 306,898 certificates from 2022, the final cause model achieved 62.65% accuracy (F1-weighted, 0.5940; F1-macro, 0.1503). The tentative cause model demonstrated 95.35% accuracy (F1-weighted, 0.9516; F1-macro, 0.4996). The individual entry model yielded 79.51% accuracy (F1-weighted, 0.7741; F1-macro, 0.9250). Error analysis indicated reduced reliability for rare diseases and for specific ICD chapters, which require supplementary administrative data.
Conclusion
Despite strong performance in mapping free-text inputs and selecting tentative underlying causes, there remains a need for improved data quality, administrative record integration, and model refinement. A systematic, long-term approach is essential for the broad adoption of AI in mortality statistics.
  • 2,103 View
  • 42 Download
  • 1 Web of Science
[English]
Purpose
This study aimed to assess the spatiotemporal associations between air pollution and emergency room visits for cardiovascular and cerebrovascular diseases in South Korea using a graph autoencoder (GAE). A multivariate graph-based approach was used to uncover seasonal and regional variations in pollutant–disease relationships.
Methods
We collected monthly data from 2022 to 2023, including concentrations of 6 air pollutants (SO2, NO2, O3, CO, PM10, and PM2.5) and emergency room visits for 4 disease types: cardiac arrest, myocardial infarction, ischemic stroke, and hemorrhagic stroke. Pearson correlation coefficients were used to construct adjacency matrices, which, along with normalized feature matrices, were used as inputs to the GAE. The model was trained separately for each month and region to estimate the strength of pollutant–disease associations.
Results
The pollutant–disease network structures exhibited clear seasonal variations. In winter, strong associations were observed between O3, NO2, and all disease outcomes. In spring, PM2.5 and PM10 were strongly linked to cardiac and stroke-related visits. These connections weakened during summer but became more pronounced in autumn, especially for NO2 and cardiac arrest. Urban areas displayed denser and stronger associations than non-urban areas.
Conclusion
Our findings underscore the necessity for season- and region-specific air quality management strategies. In winter, focused control of O3 and NO2 is needed in urban areas, while in spring, PM mitigation is required in urban and selected rural regions. Autumn NO2 control may be especially beneficial in non-urban areas. Spatiotemporally tailored interventions could reduce the burden of air pollution-related emergency room visits.
  • 2,510 View
  • 39 Download
  • 1 Web of Science
[English]
Purpose
This study developed and validated a deep learning model for the automated early detection of androgenetic alopecia (AGA) using trichoscopic images, and evaluated the model’s diagnostic performance in a Korean clinical cohort.
Methods
We conducted a retrospective observational study using 318 trichoscopic scalp images labeled by board-certified dermatologists according to the Basic and Specific (BASP) system, collected at Ewha Womans University Medical Center between July 2018 and January 2024. The images were categorized as BASP 0 (no hair loss) or BASP 1–3 (early-stage hair loss). A ResNet-18 convolutional neural network, pretrained on ImageNet, was fine-tuned for binary classification. Internal validation was performed using stratified 5-fold cross-validation, and external validation was conducted through ensemble soft voting on a separate hold-out test set of 20 images. Model performance was measured by accuracy, precision, recall, F1-score, and area under the curve (AUC), with 95% confidence intervals (CIs) calculated for hold-out accuracy.
Results
Internal validation revealed robust model performance, with 4 out of 5 folds achieving an accuracy above 0.90 and an AUC above 0.93. In external validation on the hold-out test set, the ensemble model achieved an accuracy of 0.90 (95% CI, 0.77–1.03) and an AUC of 0.97, with perfect recall for early-stage hair loss. No missing data were present, and the model demonstrated stable convergence without requiring data augmentation.
Conclusion
This model demonstrated high accuracy and generalizability for detecting early-stage AGA from trichoscopic images, supporting its potential utility as a screening tool in clinical and teledermatology settings.

Citations

Citations to this article as recorded by  
  • How Can Clinicians Leverage Vibe Coding for Machine Learning and Deep Learning Research?
    Yoonhwan Lee, Sun Huh
    Endocrinology and Metabolism.2025; 40(5): 659.     CrossRef
  • 2,477 View
  • 38 Download
  • 2 Web of Science
  • 1 Crossref
[English]
Purpose
Internal ribosome entry site (IRES) elements, present in both viral and cellular messenger RNAs (mRNAs), facilitate cap-independent translation by recruiting ribosomes to internal regions of mRNA. This study aimed to investigate the impact of inserting G-quadruplex and hairpin structures into the 5' untranslated region (UTR) and poly(A) sequences on the translation efficiency of the encephalomyocarditis virus (EMCV) IRES, using an IRES-based RNA platform encoding OX40L, 4-1BBL, and GFP.
Methods
G-quadruplex and hairpin structures, derived from HIV-1 (human immunodeficiency virus type 1) or custom-designed, were synthesized and inserted into the 5' UTR and poly(A) tail regions of EMCV IRES vectors. These constructs were amplified by polymerase chain reaction, ligated into plasmids, and transcribed in vitro. B16 melanoma, TC-1 tumor, and HEK293 cells were transfected with these RNA constructs. Protein expression levels were assessed at 6, 12, and 24 hours post-transfection by flow cytometry and fluorescence microscopy. Statistical analyses employed one-way analysis of variance with the Dunnett test.
Results
The insertion of G-quadruplex and hairpin structures altered RNA secondary structure, significantly reducing protein expression. In the 5' UTR, the G-quadruplex nearly abolished OX40L expression (1.18%±0.41% at 6 hours vs. 18.23%±0.16% for control), while the hairpin structure reduced it (16.29%±1.46% vs. 22.84%±1.17%). In the poly(A) tail region, both structures decreased GFP expression across all cell lines (4.86%±1.35% to 7.27%±0.32% vs. 39.56%±2.07% in B16 cells).
Conclusion
Inserting G-quadruplex and hairpin structures into EMCV IRES UTRs inhibits translation efficiency, suggesting the need for precise RNA structure modeling to enhance IRES-mediated translation.
  • 2,316 View
  • 53 Download
[English]
Purpose
This study compares 3 deep learning models (UNet, TransUNet, and MIST) for left atrium (LA) segmentation of cardiac computed tomography (CT) images from patients with congenital heart disease (CHD). It investigates how architectural variations in the MIST model, such as spatial squeeze-and-excitation attention, impact Dice score and HD95.
Methods
We analyzed 108 publicly available, de-identified CT volumes from the ImageCHD dataset. Volumes underwent resampling, intensity normalization, and data augmentation. UNet, TransUNet, and MIST models were trained using 80% of 97 cases, with the remaining 20% employed for validation. Eleven cases were reserved for testing. Performance was evaluated using the Dice score (measuring overlap accuracy) and HD95 (reflecting boundary accuracy). Statistical comparisons were performed via one-way repeated measures analysis of variance.
Results
MIST achieved the highest mean Dice score (0.74; 95% confidence interval, 0.67–0.81), significantly outperforming TransUNet (0.53; P<0.001) and UNet (0.49; P<0.001). Regarding HD95, TransUNet (9.09 mm) and MIST (5.77 mm) similarly outperformed UNet (27.49 mm; P<0.0001). In ablation experiments, the inclusion of spatial attention did not further enhance the MIST model’s performance, suggesting redundancy with existing attention mechanisms. However, the integration of multi-scale features and refined skip connections consistently improved segmentation accuracy and boundary delineation.
Conclusion
MIST demonstrated superior LA segmentation, highlighting the benefits of its integrated multi-scale features and optimized architecture. Nevertheless, its computational overhead complicates practical clinical deployment. Our findings underscore the value of advanced hybrid models in cardiac imaging, providing improved reliability for CHD evaluation. Future studies should balance segmentation accuracy with feasible clinical implementation.
  • 2,296 View
  • 43 Download
[English]
Purpose
This study developed and evaluated a feature-based ensemble model integrating the synthetic minority oversampling technique (SMOTE) and random undersampling (RUS) methods with a random forest approach to address class imbalance in machine learning for early diabetes detection, aiming to improve predictive performance.
Methods
Using the Scikit-learn diabetes dataset (442 samples, 10 features), we binarized the target variable (diabetes progression) at the 75th percentile and split it 80:20 using stratified sampling. The training set was balanced to a 1:2 minority-to-majority ratio via SMOTE (0.6) and RUS (0.66). A feature-based ensemble model was constructed by training random forest classifiers on 10 two-feature subsets, selected based on feature importance, and combining their outputs using soft voting. Performance was compared against 13 baseline models, using accuracy and area under the curve (AUC) as metrics on the imbalanced test set.
Results
The feature-based ensemble model and balanced random forest both achieved the highest accuracy (0.8764), followed by the fully connected neural network (0.8700). The ensemble model had an excellent AUC (0.9227), while k-nearest neighbors had the lowest accuracy (0.8427). Visualizations confirmed its superior discriminative ability, especially for the minority (high-risk) class, which is a critical factor in medical contexts.
Conclusion
Integrating SMOTE, RUS, and feature-based ensemble learning improved classification performance in imbalanced diabetes datasets by delivering robust accuracy and high recall for the minority class. This approach outperforms traditional resampling techniques and deep learning models, offering a scalable and interpretable solution for early diabetes prediction and potentially other medical applications.

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  • Leaving behind fond memories, I am stepping away from my role as editor of the Ewha Medical Journal after finalizing this issue's theme
    Sun Huh
    Ewha Medical Journal.2025; 48(4): e51.     CrossRef
  • Development and validation of an explainable prediction model for schistosomiasis seropositivity: a population-based screening study in Hunan Province, China
    Yu Zhou, Ling Tang, Mao Zheng, Benjiao Hu, Yanfeng Gong, Liyun Zhu, Liang Shi, Lei Lin, Xinran Yang, Pin Long, Yue Chen, Qingwu Jiang, Yibiao Zhou
    International Journal for Parasitology.2025; : 104766.     CrossRef
  • 2,569 View
  • 67 Download
  • 1 Web of Science
  • 2 Crossref
[English]
Purpose
Accurate prediction of blood glucose variability is crucial for effective diabetes management, as both hypoglycemia and hyperglycemia are associated with increased morbidity and mortality. However, conventional predictive models rely primarily on patient-specific biometric data, often neglecting the influence of patient–provider interactions, which can significantly impact outcomes. This study introduces Cyclic Dual Latent Discovery (CDLD), a deep learning framework that explicitly models patient–provider interactions to improve prediction of blood glucose levels. By leveraging a real-world intensive care unit (ICU) dataset, the model captures latent attributes of both patients and providers, thus improving forecasting accuracy.
Methods
ICU patient records were obtained from the MIMIC-IV v3.0 critical care database, including approximately 5,014 instances of patient–provider interaction. The CDLD model uses a cyclic training mechanism that alternately updates patient and provider latent representations to optimize predictive performance. During preprocessing, all numeric features were normalized, and extreme glucose values were capped at 500 mg/dL to mitigate the effect of outliers.
Results
CDLD outperformed conventional models, achieving a root mean square error of 0.0852 on the validation set and 0.0899 on the test set, which indicates improved generalization. The model effectively captured latent patient–provider interaction patterns, yielding more accurate glucose variability predictions than baseline approaches.
Conclusion
Integrating patient–provider interaction modeling into predictive frameworks can increase blood glucose prediction accuracy. The CDLD model offers a novel approach to diabetes management, potentially paving the way for artificial intelligence-driven personalized treatment strategies.
  • 1,525 View
  • 35 Download
[English]
Purpose
This study aimed to leverage Shapley additive explanation (SHAP)-based feature engineering to predict appendix cancer. Traditional models often lack transparency, hindering clinical adoption. We propose a framework that integrates SHAP for feature selection, construction, and weighting to enhance accuracy and clinical relevance.
Methods
Data from the Kaggle Appendix Cancer Prediction dataset (260,000 samples, 21 features) were used in this prediction study conducted from January through March 2025, in accordance with TRIPOD-AI guidelines. Preprocessing involved label encoding, SMOTE (synthetic minority over-sampling technique) to address class imbalance, and an 80:20 train-test split. Baseline models (random forest, XGBoost, LightGBM) were compared; LightGBM was selected for its superior performance (accuracy=0.8794). SHAP analysis identified key features and guided 3 engineering steps: selection of the top 15 features, construction of interaction-based features (e.g., chronic severity), and feature weighting based on SHAP values. Performance was evaluated using accuracy, precision, recall, and F1-score.
Results
Four LightGBM model configurations were evaluated: baseline (accuracy=0.8794, F1-score=0.8691), feature selection (accuracy=0.8968, F1-score=0.8860), feature construction (accuracy=0.8980, F1-score=0.8872), and feature weighting (accuracy=0.8986, F1-score=0.8877). SHAP-based engineering yielded performance improvements, with feature weighting achieving the highest precision (0.9940). Key features (e.g., red blood cell count and chronic severity) contributed to predictions while maintaining interpretability.
Conclusion
The SHAP-based framework substantially improved the accuracy and transparency of appendix cancer predictions using LightGBM (F1-score=0.8877). This approach bridges the gap between predictive power and clinical interpretability, offering a scalable model for rare disease prediction. Future validation with real-world data is recommended to ensure generalizability.

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  • Feature engineering and explainable artificial intelligence for state of health estimation of Lithium-ion batteries
    Tugba Tetik
    Journal of Energy Storage.2026; 144: 119873.     CrossRef
  • Uncovering Key Factors of Student Performance in Math: An Explainable Deep Learning Approach Using TIMSS 2019 Data
    Abdelamine Elouafi, Ilyas Tammouch, Souad Eddarouich, Raja Touahni
    Information.2025; 16(6): 480.     CrossRef
  • Concurrent high-grade appendiceal mucinous neoplasm and adenocarcinoma: a unique case report and literature review
    Mohammed N AlAli, Jawad S Alnajjar, Mohamed S Essa, Arwa F Alrasheed, Ruba M Alzuhairi, Nouf A Alromaih, Sadiq M Amer, Mohammed Sbaih
    Journal of Surgical Case Reports.2025;[Epub]     CrossRef
  • Infrared window properties of AB₂C₄ (A=Zn; B In, Ga; C Te, Se) materials via machine learning and density functional theory
    Changcheng Chen, Chunlian Xiong, Xinhui Zhang, Chunling Zhang, Yue Cheng, Weijun Wang, Wenkang Yu, Xunzhe Zhang, Jinkang Yu, Zhengjun Wang, Xiaoning Guan, Jiangzhou Xie, Yaxin Xu, Gang Liu, Pengfei Lu
    Journal of Alloys and Compounds.2025; 1044: 184560.     CrossRef
  • Advanced Computational Modeling and Machine Learning for Risk Stratification, Treatment Optimization, and Prognostic Forecasting in Appendiceal Neoplasms
    Jawad S. Alnajjar, Faisal A. Al-Harbi, Ahmed Khalifah Alsaif, Ghaida S. Alabdulaaly, Omar K. Aljubaili, Manal Alquaimi, Arwa F. Alrasheed, Mohammed N. AlAli, Maha A. Alghamdi, Ahmed Y. Azzam
    Healthcare.2025; 13(23): 3074.     CrossRef
  • 7,442 View
  • 94 Download
  • 5 Web of Science
  • 5 Crossref

Review article

[English]
Relationship between periodontitis and systemic health conditions: a narrative review
Min-Young Kim, Eun-Kyoung Pang
Ewha Med J 2025;48(2):e27.   Published online April 14, 2025
DOI: https://doi.org/10.12771/emj.2025.00101
This review examines the bidirectional relationship between periodontitis and systemic health conditions, offering an integrated perspective based on current evidence. It synthesizes epidemiological data, biological mechanisms, and clinical implications to support collaborative care strategies recognizing oral health as a key component of overall wellness. Periodontitis affects 7.4% to 11.2% of adults worldwide, and its prevalence increases with age. Beyond its local effects, including gingival inflammation, periodontal pocket formation, and alveolar bone loss, periodontitis is associated with various systemic conditions. Emerging evidence has established links with obesity, diabetes mellitus, cardiovascular disease, chronic kidney disease, inflammatory bowel disease, rheumatoid arthritis, respiratory diseases, adverse pregnancy outcomes, certain malignancies, neurodegenerative diseases, psychological disorders, and autoimmune conditions. These associations are mediated by 3 primary mechanisms: dysbiotic oral biofilms, chronic low-grade systemic inflammation, and the dissemination of periodontal pathogens throughout the body. The pathophysiology involves elevated levels of pro-inflammatory cytokines (including interleukin 6, tumor necrosis factor alpha, and C-reactive protein), impaired immune function, oxidative stress, and molecular mimicry. Periodontal pathogens, particularly Porphyromonas gingivalis, are crucial in initiating and sustaining systemic inflammatory responses. Treatment of periodontitis has demonstrated measurable improvements in numerous systemic conditions, emphasizing the clinical significance of these interconnections. Periodontitis should be understood as more than just a localized oral disease; it significantly contributes to the overall systemic inflammatory burden, with implications for general health. An integrated, multidisciplinary approach to prevention, early detection, and comprehensive treatment is vital for optimal patient outcomes. Healthcare providers should acknowledge oral health as an essential element of systemic well-being.

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  • Cannabinoid Signaling and Autophagy in Oral Disease: Molecular Mechanisms and Therapeutic Implications
    Undral Munkhsaikhan, Md Ataur Rahman, Alivia Shasteen, Karima Ait-Aissa, Amal M. Sahyoun, Rajat Das Gupta, Modar Kassan, Ehsanul Hoque Apu, Ammaar H. Abidi
    International Journal of Molecular Sciences.2026; 27(1): 525.     CrossRef
  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • The Correlations Between Diabetes Mellitus and Oro-Maxillofacial Disorders: A Statistical Perspective
    Ionut Catalin Botezatu, Mihaela Salceanu, Ana Emanuela Botez, Cristina Daniela Dimitriu, Oana Elena Ciurcanu, Claudiu Topoliceanu, Elena-Carmen Cotrutz, Maria-Alexandra Martu
    Dentistry Journal.2025; 13(8): 373.     CrossRef
  • Association between periodontal disease and Alzheimer's disease: a scoping review
    Xiaocui Zhang, Xin Huang, Mengdie Chang
    Frontiers in Aging Neuroscience.2025;[Epub]     CrossRef
  • Salivary Investigation of the Complex Relationship between NLRP3 Inflammasome, Leptin and Total Antioxidant Capacity in the Context of Periodontal Disease
    Iulia I. Stanescu-Spinu, Ilinca Radu , Tudor C. Spinu , Daniela Miricescu , Anca S. Dumitriu , Brandusa F. Mocanu , Silviu C. Badoiu , Anca M. Coricovac , Andreea C. Didilescu
    Romanian Journal of Military Medicine.2025; 128(6): 536.     CrossRef
  • Four-Year Longitudinal Epidemiological Study on the Association Between a Multi-Item Saliva Testing System and Oral and Gut Microbiota
    Satoshi Sato, Daisuke Chinda, Keita Mikami, Masakazu Tobinai, Nao Ishidoya, Keisuke Furusawa, Kaede Miyashiro, Kenta Yoshida, Chikara Iino, Kaori Sawada, Tatsuya Mikami, Shigeyuki Nakaji, Koichi Murashita, Hirotake Sakuraba
    Microorganisms.2025; 13(11): 2483.     CrossRef
  • Oral microbiota in hemodialysis patients; a narrative review on recent ideas
    Mayyadah Hameed Rashid, Haifaa Abdulameer Radhi, Aseel Abdulameer Radhi
    Journal of Renal Injury Prevention.2025; 14(4): e38685.     CrossRef
  • 14,542 View
  • 274 Download
  • 7 Web of Science
  • 7 Crossref

Original article

[English]
Status of human rights violations and trauma among North Korean defectors: a cross-sectional study
So Hee Lee, Won Woong Lee, Haewoo Lee, Jin Yong Jun, Jin-Won Noh
Ewha Med J 2025;48(2):e28.   Published online April 10, 2025
DOI: https://doi.org/10.12771/emj.2025.00367
Purpose
This study aimed to identify the types of human rights violations and the associated psychological trauma experienced by North Korean defectors. It also examined the impact of trauma on the defectors’ interpersonal relationships, employment, and overall quality of life, while evaluating existing psychological support policies to suggest potential improvements.
Methods
A multidisciplinary research team conducted an observational survey and in-depth interviews with approximately 300 North Korean defectors residing in South Korea from June to September 2017. Standardized measurement tools, including the Post-Traumatic Stress Disorder (PTSD) Checklist (PCL-5), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder Scale-7 (GAD-7), and Short Form-8 Health Survey (SF-8), were employed. Statistical analyses consisted of frequency analysis, cross-tabulation, factor analysis, and logistic regression.
Results
The findings revealed a high prevalence of human rights violations, such as public executions (82%), forced self-criticism (82.3%), and severe starvation or illness (62.7%). Additionally, there were elevated rates of PTSD (56%), severe depression (28.3%), anxiety (25%), and insomnia (23.3%). Defectors who resided in China before entering South Korea reported significantly worse mental health outcomes and a lower quality of life. Moreover, trauma was strongly and negatively correlated with social adjustment, interpersonal relationships, employment stability, and overall well-being.
Conclusion
An urgent revision of existing policies is needed to incorporate specialized, trauma-informed care infrastructures within medical institutions. Furthermore, broad societal education to reduce stigma and enhance integration efforts is essential to effectively support the psychological well-being and social integration of North Korean defectors.

Citations

Citations to this article as recorded by  
  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • 7,840 View
  • 101 Download
  • 1 Web of Science
  • 1 Crossref

Review article

[English]
Heart failure (HF) represents a significant global health burden characterized by high morbidity, mortality, and healthcare utilization. Traditional in-person care models face considerable limitations in providing continuous monitoring and timely interventions for HF patients. Telemedicine—defined as the remote delivery of healthcare via information and communication technologies—has emerged as a promising solution to these challenges. This review examines the evolution, current applications, clinical evidence, limitations, and future directions of telemedicine in HF management. Evidence from randomized controlled trials and meta-analyses indicates that telemedicine interventions can improve guideline-directed medical therapy implementation, reduce hospitalization rates, improve patient engagement, and potentially decrease mortality among HF patients. Remote monitoring systems that track vital signs, symptoms, and medication adherence allow for the early detection of clinical deterioration, enabling timely interventions before decompensation occurs. Despite these benefits, telemedicine implementation faces several barriers, including technological limitations, reimbursement issues, digital literacy gaps, and challenges in integrating workflows. Future directions include developing standardized guidelines, designing patient-centered technologies, and establishing hybrid care models that combine virtual and in-person approaches. As healthcare systems worldwide seek more efficient and effective strategies for managing the growing population of individuals with HF, telemedicine offers a solution that may significantly improve patient outcomes and quality of life.

Citations

Citations to this article as recorded by  
  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • Impact of Telemedicine Technologies on Treatment Adherence in Patients with Chronic Heart Failure: a Systematic Review and Meta-Analysis
    A. A. Garanin, O. A. Rubanenko, Yu. A. Trusov, D. V. Senyushkin, A. V. Kolsanov
    Kardiologiia.2025; 65(10): 27.     CrossRef
  • 10,962 View
  • 94 Download
  • 2 Web of Science
  • 2 Crossref

Original article

[English]
Immunogenicity of Anisakis larvae molting membrane against human eosinophilia sera
Sooji Hong, Bong-Kwang Jung, Hyun-Jong Yang
Ewha Med J 2025;48(2):e29.   Published online April 8, 2025
DOI: https://doi.org/10.12771/emj.2025.00311
Purpose
This study aimed to investigate whether proteins present in the molting membranes of third-stage (L3) Anisakis larvae could serve as potential risk factors for allergic reactions.
Methods
Third-stage larvae (L3) of Anisakis spp. were primarily collected from mackerels and cultured in vitro to yield both molting membranes and fourth-stage (L4) larvae. Major soluble proteins in the molting membranes were identified using SDS-PAGE (sodium dodecyl sulfate–polyacrylamide gel electrophoresis). Crude antigens extracted from L3, L4, and the molting membranes were subsequently evaluated by western blotting using sera from Anisakis-infected rabbits and patients with eosinophilia.
Results
Antigens derived from the molting membranes reacted with sera from Anisakis-infected rabbits as well as with sera from 7 patients with eosinophilia of unknown origin. These findings suggest that unidentified proteins in the molting membranes of Anisakis L3 may contribute to early allergic reactions, particularly in patients sensitized by specific molecular components.
Conclusion
Our results indicate that proteins present in the molting membranes of third-stage Anisakis spp. larvae may be associated with allergic responses. Further studies are required to confirm the correlation between these membranes and Anisakis-induced allergies.

Citations

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  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • 1,174 View
  • 24 Download
  • 1 Web of Science
  • 1 Crossref

Review article

[English]
Recent advancements in tuberculosis treatment research emphasize innovative strategies that enhance treatment efficacy, reduce adverse effects, and adhere to patient-centered care principles. As tuberculosis remains a significant global health challenge, integrating new and repurposed drugs presents promising avenues for more effective management, particularly against drug-resistant strains. Recently, the spectrum concept in tuberculosis infection and disease has emerged, underscoring the need for research aimed at developing treatment plans specific to each stage of the disease. The application of precision medicine to tailor treatments to individual patient profiles is crucial for addressing the diverse and complex nature of tuberculosis infections. Such personalized approaches are essential for optimizing therapeutic outcomes and improving patient adherence—both of which are vital for global tuberculosis eradication efforts. The role of tuberculosis cohort studies is also emphasized, as they provide critical data to support the development of these tailored treatment plans and deepen our understanding of disease progression and treatment response. To advance these innovations, a robust tuberculosis policy framework is required to foster the integration of research findings into practice, ensuring that treatment innovations are effectively translated into improved health outcomes worldwide.

Citations

Citations to this article as recorded by  
  • Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB)
    Chiwook Chung, Jinsoo Min, Doosoo Jeon, Yong-Soo Kwon, Jeongha Mok, Hyung Woo Kim, Youngmok Park, Young Ae Kang
    Tuberculosis and Respiratory Diseases.2026; 89(1): 86.     CrossRef
  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • 4,339 View
  • 100 Download
  • 1 Web of Science
  • 2 Crossref

Original article

[English]
Development of automatic organ segmentation based on positron-emission tomography analysis system using Swin UNETR in breast cancer patients in Korea
Dong Hyeok Choi, Joonil Hwang, Hai-Jeon Yoon, So Hyun Ahn
Ewha Med J 2025;48(2):e30.   Published online April 2, 2025
DOI: https://doi.org/10.12771/emj.2025.00094
Purpose
The standardized uptake value (SUV) is a key quantitative index in nuclear medicine imaging; however, variations in region‐of‐interest (ROI) determination exist across institutions. This study aims to standardize SUV evaluation by introducing a deep learning‐based quantitative analysis method that enhances diagnostic and prognostic accuracy.
Methods
We used the Swin UNETR model to automatically segment key organs (breast, liver, spleen, and bone marrow) critical for breast cancer prognosis. Tumor segmentation was performed iteratively based on predefined SUV thresholds, and prognostic information was extracted from the liver, spleen, and bone marrow (reticuloendothelial system). The artificial intelligence training process employed 3 datasets: a test dataset (40 patients), a validation dataset (10 patients), and an independent test dataset (10 patients). To validate our approach, we compared the SUV values obtained using our method with those produced by commercial software.
Results
In a dataset of 10 patients, our method achieved an auto‐segmentation accuracy of 0.9311 for all target organs. Comparison of maximum SUV and mean SUV values from our automated segmentation with those from traditional single‐ROI methods revealed differences of 0.19 and 0.16, respectively, demonstrating improved reliability and accuracy in whole‐organ SUV analysis.
Conclusion
This study successfully standardized SUV calculation in nuclear medicine imaging through deep learning‐based automated organ segmentation and SUV analysis, significantly enhancing accuracy in predicting breast cancer prognosis.
  • 1,476 View
  • 44 Download

Health statistics

[English]
Dementia-related death statistics in Korea between 2013 and 2023
Seokmin Lee
Ewha Med J 2025;48(2):e35.   Published online March 31, 2025
DOI: https://doi.org/10.12771/emj.2025.00304
Purpose
This study aimed to analyze dementia-related death statistics in Korea between 2013 and 2023.
Methods
The analysis utilized microdata from Statistics Korea’s cause-of-death statistics. Among all recorded deaths, those related to dementia were extracted and analyzed using the underlying cause-of-death codes from the International Classification of Diseases, 10th revision.
Results
The number of dementia-related deaths increased from 8,688 in 2013 to 14,402 in 2023. The crude death rate rose from 17.2 per 100,000 in 2013 to 28.2 per 100,000 in 2023, although the age-standardized death rate declined from 9.7 to 8.7 over the same period. The dementia death rate is 2.1 times higher in women than in men, and mortality among individuals aged 85 and older exceeds 976 per 100,000. By specific cause, Alzheimer’s disease accounted for 77.1% of all dementia deaths, and by place, the majority occurred in hospitals (76.2%), followed by residential institutions including nursing homes (15.3%) in 2023.
Conclusion
The rising mortality associated with dementia, especially Alzheimer’s disease, highlights a growing public health concern in Korea. These findings support the need for enhanced prevention efforts, improved quality of care, and targeted policies addressing the complexities of dementia management. It is anticipated that this empirical analysis will contribute to reducing the social burden.

Citations

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  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • 9,599 View
  • 51 Download
  • 1 Web of Science
  • 1 Crossref

Review articles

[English]
The Mycobacterium avium complex (MAC), comprising M. avium and M. intracellulare, constitutes the predominant cause of nontuberculous mycobacterial pulmonary disease (NTM-PD) in Korea, followed by the M. abscessus complex. Its global prevalence is increasing, as shown by a marked rise in Korea from 11.4 to 56.7 per 100,000 individuals between 2010 and 2021, surpassing the incidence of tuberculosis. Among the older adult population (aged ≥65 years), the prevalence escalated from 41.9 to 163.1 per 100,000, accounting for 47.6% of cases by 2021. Treatment should be individualized based on prognostic indicators, including cavitary disease, low body mass index, and positive sputum smears for acid-fast bacilli. Current therapeutic guidelines recommend a 3-drug regimen—consisting of a macrolide, rifampin, and ethambutol—administered for a minimum of 12 months following culture conversion. Nevertheless, treatment success rates are only roughly 60%, and over 30% of patients experience recurrence. This is often attributable to reinfection rather than relapse. Antimicrobial susceptibility testing for clarithromycin and amikacin is essential, as resistance significantly worsens prognosis. Ethambutol plays a crucial role in preventing the development of macrolide resistance, whereas the inclusion of rifampin remains a subject of ongoing debate. Emerging therapeutic strategies suggest daily dosing for milder cases, increased azithromycin dosing, and the substitution of rifampin with clofazimine in severe presentations. Surgical resection achieves a notable sputum conversion rate of approximately 93% in eligible candidates. For refractory MAC-PD, adjunctive therapy with amikacin is advised, coupled with strategies to reduce environmental exposure. Despite advancements in therapeutic approaches, patient outcomes remain suboptimal, highlighting the urgent need for novel interventions.

Citations

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  • Bidirectional pathogenesis between non-tuberculous mycobacteria and bronchiectasis: clinical insights, diagnostic challenges and future directions—Perspectives from South Asia
    Amresh Kumar Singh, Sneha Singh, Nandini Singh, Priyanka Gaur, Ashwini Kumar Mishra, Raj Kishore Singh, Sushil Kumar
    Frontiers in Tuberculosis.2026;[Epub]     CrossRef
  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • Understanding recurrence in Mycobacterium avium complex pulmonary disease: genotypic strategies to support clinical decision-making
    Minh Phuong Trinh, Sung Jae Shin, Min-Kyoung Shin, Mark Nicol
    Journal of Clinical Microbiology.2025;[Epub]     CrossRef
  • 13,995 View
  • 220 Download
  • 2 Web of Science
  • 3 Crossref
[English]
Impact of pulmonary tuberculosis on lung cancer screening: a narrative review
Jeong Uk Lim
Ewha Med J 2025;48(2):e23.   Published online March 26, 2025
DOI: https://doi.org/10.12771/emj.2025.00052
Lung cancer remains a leading cause of cancer-related mortality worldwide. Low-dose computed tomography (LDCT) screening has demonstrated efficacy in reducing lung cancer mortality by enabling early detection. In several countries, including Korea, LDCT-based screening for high-risk populations has been incorporated into national healthcare policies. However, in regions with a high tuberculosis (TB) burden, the effectiveness of LDCT screening for lung cancer may be influenced by TB-related pulmonary changes. Studies indicate that the screen-positive rate in TB-endemic areas differs from that in low-TB prevalence regions. A critical challenge is the differentiation between lung cancer lesions and TB-related abnormalities, which can contribute to false-positive findings and increase the likelihood of unnecessary invasive procedures. Additionally, structural lung damage from prior TB infections can alter LDCT interpretation, potentially reducing diagnostic accuracy. Nontuberculous mycobacterial infections further complicate this issue, as their radiologic features frequently overlap with those of TB and lung cancer, necessitating additional microbiologic confirmation. Future research incorporating artificial intelligence and biomarkers may enhance diagnostic precision and facilitate a more personalized approach to lung cancer screening in TB-endemic settings.

Citations

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  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • 5,261 View
  • 62 Download
  • 1 Web of Science
  • 1 Crossref
[English]
Chronic obstructive pulmonary disease (COPD) is a leading cause of respiratory morbidity and mortality, most often linked to smoking. However, growing evidence indicates that previous tuberculosis (TB) infection is also a critical risk factor for COPD. This review aimed at providing a comprehensive perspective on TB-COPD, covering its epidemiologic significance, pathogenesis, clinical characteristics, and current management approaches. Tuberculosis-associated chronic obstructive pulmonary disease (TB-COPD) is characterized by persistent inflammatory responses, altered immune pathways, and extensive structural lung damage—manifested as cavitation, fibrosis, and airway remodeling. Multiple epidemiologic studies have shown that individuals with a history of TB have a significantly higher likelihood of developing COPD and experiencing worse outcomes, such as increased breathlessness and frequent exacerbations. Key pathogenic mechanisms include elevated matrix metalloproteinase activity and excessive neutrophil-driven inflammation, which lead to alveolar destruction, fibrotic scarring, and the development of bronchiectasis. Treatment generally follows current COPD guidelines, advocating the use of long-acting bronchodilators and the selective application of inhaled corticosteroids. Studies have demonstrated that indacaterol significantly improves lung function and respiratory symptoms, while long-acting muscarinic antagonists have shown survival benefits.

Citations

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  • Recent advances in pulmonary tuberculosis, the application of deep learning to medical topics, and highlights from this issue of Ewha Medical Journal
    Hae-Sun Chung
    Ewha Medical Journal.2025; 48(2): e16.     CrossRef
  • History of Pulmonary Tuberculosis Accelerates Early Onset and Severity of COPD: Evidence from a Multicenter Study in Romania
    Ramona Cioboata, Silviu Gabriel Vlasceanu, Denisa Maria Mitroi, Ovidiu Mircea Zlatian, Mara Amalia Balteanu, Gabriela Marina Andrei, Viorel Biciusca, Mihai Olteanu
    Journal of Clinical Medicine.2025; 14(17): 5980.     CrossRef
  • Bidirectional Association Between Tuberculosis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
    Jingyuan Feng, Minghao Hu, Hongfei Duan
    Journal of Clinical Medicine.2025; 14(21): 7639.     CrossRef
  • Immune Mechanisms of the Comorbid Course of Chronic Obstructive Pulmonary Disease and Tuberculosis
    Stanislav Kotlyarov, Dmitry Oskin
    BIOCELL.2025; 49(9): 1631.     CrossRef
  • Chronic Obstructive Pulmonary Disease in Never-Smokers—A Distinct Entity Within the COPD Spectrum
    Andreea-Nicoleta Mălăescu, Florin-Dumitru Mihălțan, Ancuța-Alina Constantin
    Life.2025; 16(1): 43.     CrossRef
  • 10,718 View
  • 343 Download
  • 5 Web of Science
  • 5 Crossref

Special topic: role of institutes related to the occupational and environmental diseases in Korea

[English]
Occupational disease monitoring by the Korea Occupational Disease Surveillance Center: a narrative review
Dong-Wook Lee, Inah Kim, Jungho Hwang, Sunhaeng Choi, Tae-Won Jang, Insung Chung, Hwan-Cheol Kim, Jaebum Park, Jungwon Kim, Kyoung Sook Jeong, Youngki Kim, Eun-Soo Lee, Yangwoo Kim, Inchul Jeong, Hyunjeong Oh, Hyeoncheol Oh, Jea Chul Ha, Jeehee Min, Chul Gab Lee, Heon Kim, Jaechul Song
Ewha Med J 2025;48(1):e9.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e9

This review examines the challenges associated with occupational disease surveillance in Korea, particularly emphasizing the limitations of current data sources such as the Industrial Accident Compensation Insurance (IACI) statistics and special health examinations. The IACI system undercounts cases due to its emphasis on severe diseases and restrictions on approvals. Special health examinations, although they cover a broad workforce, are constrained by their annual scheduling, which leads to missed acute illnesses and subclinical conditions. The paper also explores the history of occupational disease surveillance in Korea, highlighting the fragmented and disease-specific approach of earlier systems. The authors introduce the newly established Korea Occupational Disease Surveillance Center (KODSC), a comprehensive nationwide system designed to gather, analyze, and interpret data on occupational diseases through a network of regional centers. By incorporating hospital-based surveillance and focusing on acute poisonings and other sentinel events, the KODSC aims to overcome the limitations of previous systems and promote collaboration with various agencies. Although it is still in the early stages of implementation, the KODSC demonstrates potential for improving data accuracy and contributing valuable insights for public health policy.

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  • Occupational Toxic Effect Episodes in a University Hospital, 2021–2024: A Descriptive Analysis Within the Korean Occupational Disease Surveillance Center
    Yangwoo Kim, Ha-Eun Lee, Jei Kim, Tae-Won Jang
    Safety and Health at Work.2025;[Epub]     CrossRef
  • Occupational and Environmental Health Screening Cohort of Yangsan Korea (OEC-YK): 2012–2023
    Dongmug Kang, Eun-Soo Lee, Se-Yeong Kim, Youngki Kim, Youn Hyang Lee, Yoon-Ji Kim
    Annals of Occupational and Environmental Medicine.2025; 37: e32.     CrossRef
  • 9,603 View
  • 81 Download
  • 2 Web of Science
  • 2 Crossref

Special topic: recent clinical approach to shoulder diseases in older adults

[English]
Physical examinations for older adults with shoulder pain: a narrative review
Sangwoo Kang, Suk-Woong Kang
Ewha Med J 2025;48(1):e8.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e8

Shoulder pain is a common complaint in primary care settings. The prevalence of shoulder pain is on the rise, especially in societies with aging populations. Like other joint-related conditions, shoulder pain is predominantly caused by degenerative diseases. These degenerative changes typically affect bones, tendons, and cartilage, with common conditions including degenerative rotator cuff tears, impingement syndrome, and osteoarthritis. Diagnosing these degenerative diseases in older adults requires a thorough understanding of basic anatomy, general physical examination techniques, and specific diagnostic tests. This review aims to outline the fundamental physical examination methods for diagnosing shoulder pain in older adult patients in primary care. The shoulder's complex anatomy and its broad range of motion underscore the need for a systematic approach to evaluation. Routine inspection and palpation can identify signs such as muscle atrophy, bony protrusions, or indications of degenerative changes. Assessing range of motion, and distinguishing between active and passive deficits, is crucial for differentiating conditions like frozen shoulder from rotator cuff tears. Targeted strength tests, such as the empty can, external rotation lag, liftoff, and belly press tests, are instrumental in isolating specific rotator cuff muscles. Additionally, impingement tests, including Neer’s and Hawkins’ signs, are useful for detecting subacromial impingement. A comprehensive understanding of shoulder anatomy and a systematic physical examination are vital for accurately diagnosing shoulder pain in older adults. When properly executed and interpreted in the clinical context, these maneuvers help differentiate between various conditions, ranging from degenerative changes to rotator cuff pathology.

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  • 106 Download

Special topic: role of institutes related to the occupational and environmental diseases in Korea

[English]
Challenges from 14 years of experience at Workers' Health Centers in basic occupational health services for micro and small enterprises in Korea: a narrative review
Jeong-Ok Kong, Yeongchull Choi, Seonhee Yang, Kyunghee Jung-Choi
Ewha Med J 2025;48(1):e7.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e7

Health and safety issues in micro and small enterprises (MSEs) are recognized as a global challenge. This study aimed to examine Workers' Health Centers (WHCs) as a representative public organization providing occupational health services to MSEs in Korea. WHCs were established in 2011 after a trial period aimed at addressing occupational diseases in MSEs with limited resources. As of 2024, there are 24 WHCs, 22 branch offices, and 23 trauma counseling centers for workers. These health centers are managed by the Korea Occupational Safety and Health Agency, with their actual operation delegated to private organizations. Each WHC employs an average of 13 staff members and is organized into four specialized teams: cardiovascular disease prevention, workplace environment improvement, musculoskeletal disease prevention, and occupational stress management. These centers also offer common basic programs along with region-specific specialized initiatives. In 2023, the total cumulative number of users reached 203,877, with employees from MSEs comprising approximately 88.5% of the total. WHCs can thus be seen as playing a pivotal role as case managers of health requirements in the workplace by fostering strong relationships with MSEs and linking them to other relevant programs through a problem-solving-oriented approach. Given the limited resources of these enterprises, proactive policies and the equitable application of safety and health regulations are essential. A balanced strategy that combines regulatory enforcement with practical assistance is critical to ensure the success of WHCs in improving health and safety conditions in MSEs.

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  • 33 Download

Special topic: recent clinical approach to shoulder diseases in older adults

[English]

Shoulder diseases pose a significant health challenge for older adults, often causing pain, functional decline, and decreased independence. This narrative review explores how deep learning (DL) can address diagnostic challenges by automating tasks such as image segmentation, disease detection, and motion analysis. Recent research highlights the effectiveness of DL-based convolutional neural networks and machine learning frameworks in diagnosing various shoulder pathologies. Automated image analysis facilitates the accurate assessment of rotator cuff tear size, muscle degeneration, and fatty infiltration in MRI or CT scans, frequently matching or surpassing the accuracy of human experts. Convolutional neural network-based systems are also adept at classifying fractures and joint conditions, enabling the rapid identification of common causes of shoulder pain from plain radiographs. Furthermore, advanced techniques like pose estimation provide precise measurements of the shoulder joint's range of motion and support personalized rehabilitation plans. These automated approaches have also been successful in quantifying local osteoporosis, utilizing machine learning-derived indices to classify bone density status. DL has demonstrated significant potential to improve diagnostic accuracy, efficiency, and consistency in the management of shoulder diseases in older patients. Machine learning-based assessments of imaging data and motion parameters can help clinicians optimize treatment plans and improve patient outcomes. However, to ensure their generalizability, reproducibility, and effective integration into routine clinical workflows, large-scale, prospective validation studies are necessary. As data availability and computational resources increase, the ongoing development of DL-driven applications is expected to further advance and personalize musculoskeletal care, benefiting both healthcare providers and the aging population.

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  • 32 Download
[English]
Classification of shoulder diseases in older adult patients: a narrative review
Hyo-Jin Lee, Jong-Ho Kim
Ewha Med J 2025;48(1):e5.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e5

This review classifies and summarizes the major shoulder diseases affecting older adults, focusing on rotator cuff disease, frozen shoulder, osteoarthritis, and shoulder instability. It explores each condition's pathophysiology, risk factors, clinical presentation, diagnostic approaches, and treatment strategies to guide clinicians in optimizing patient outcomes and enhancing quality of life. Age-related degenerative changes, comorbidities, and distinct etiological factors contribute to the presentation of shoulder disorders in older adults. Rotator cuff disease ranges from tendinopathy to full-thickness tears and is influenced by genetic predispositions, inflammatory cytokines, and muscle quality. Frozen shoulder results from fibroproliferative changes in the capsule, leading to significant pain and restricted motion. Osteoarthritis involves cartilage degeneration and bony remodeling, often necessitating surgical interventions such as arthroplasty. Shoulder instability, though less frequent, is complicated by associated injuries like rotator cuff tears and fractures, requiring tailored management strategies. Advances in imaging techniques, biologic treatments, and surgical procedures, particularly arthroscopic and arthroplasty options, have improved diagnostic accuracy and therapeutic outcomes. A thorough classification of shoulder diseases in older adult patients highlights the complexity of managing these conditions. Effective treatment requires individualized approaches that integrate conservative measures with emerging biologic or surgical therapies. Future research should focus on targeted interventions, standardized diagnostic criteria, and multidisciplinary collaboration to minimize disability, optimize function, and improve overall quality of life in this growing patient population. Multimodal strategies, including patient education, structured rehabilitation, and psychosocial support, further enhance long-term adherence and outcomes. Ongoing vigilance for comorbidities, such as osteoporosis or metabolic disorders, is necessary for comprehensive care.

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  • 57 Download

Special topic: role of institutes related to the occupational and environmental diseases in Korea

[English]
Environmental disease monitoring by regional Environmental Health Centers in Korea: a narrative review
Myung-Sook Park, Hwan-Cheol Kim, Woo Jin Kim, Yun-Chul Hong, Won-Jun Choi, Seock-Yeon Hwang, Jiho Lee, Young-Seoub Hong, Yong-Dae Kim, Seong-Chul Hong, Joo Hyun Sung, Inchul Jeong, Kwan Lee, Won-Ju Park, Hyun-Joo Bae, Seong-Yong Yoon, Cheolmin Lee, Kyoung Sook Jeong, Sanghyuk Bae, Jinhee Choi, Ho-Hyun Kim
Ewha Med J 2025;48(1):e3.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e3

This study explores the development, roles, and key initiatives of the Regional Environmental Health Centers in Korea, detailing their evolution through four distinct phases and their impact on environmental health policy and local governance. It chronicles the establishment and transformation of these centers from their inception in May 2007, through four developmental stages. Originally named Environmental Disease Research Centers, they were subsequently renamed Environmental Health Centers following legislative changes. The analysis includes the expansion in the number of centers, the transfer of responsibilities to local governments, and the launch of significant projects such as the Korean Children’s Environmental Health Study (Ko-CHENS ). During the initial phase (May 2007–February 2009), the 10 centers concentrated on research-driven activities, shifting from a media-centered to a receptor-centered approach. In the second phase, prompted by the enactment of the Environmental Health Act, six additional centers were established, broadening their scope to address national environmental health issues. The third phase introduced Ko-CHENS, a 20-year national cohort project designed to influence environmental health policy by integrating research findings into policy frameworks. The fourth phase marked a decentralization of authority, empowering local governments and redefining the centers' roles to focus on regional environmental health challenges. The Regional Environmental Health Centers have significantly evolved and now play a crucial role in addressing local environmental health issues and supporting local government policies. Their capacity to adapt and respond to region-specific challenges is essential for the effective implementation of environmental health policies, reflecting geographical, socioeconomic, and demographic differences.

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  • 29 Download

Original Article

Original Articles

[English]

Objectives: This study aimed to evaluate the effectiveness of a multidisciplinary pulmonary rehabilitation program at Ewha Womans University Mokdong Hospital, Korea that was designed to augment respiratory function, promote patient recovery, and improve discharge outcomes.

Methods: This study was conducted as part of quality improvement activities from March to August 2023. A multidisciplinary pulmonary rehabilitation team was established, comprising specialists in rehabilitation medicine, pulmonology, and thoracic surgery, as well as physical and occupational therapists, and the nutrition team. We developed a comprehensive rehabilitation program that included stretching, strengthening exercises, aerobic training, and respiratory retraining, supplemented by individualized treatments such as bedside and ambulatory physical therapy. Evaluations before and after rehabilitation were performed using the Modified Medical Research Council Dyspnea Scale and the Chronic Obstructive Pulmonary Disease Assessment Test. The primary indicators of success were an increase of over 10% in pulmonary rehabilitation consultations and an improvement in discharge-to-home rates.

Results: The total number of pulmonary rehabilitation cases rose by 79.16%, from 24 to 43, while consultations saw a 21.15% increase, from 52 to 63. Of the 63 pulmonary rehabilitation cases, 32 (50.8%) were transferred to other hospitals, 25 (39.7%) were discharged home, and 6 (9.5%) remained hospitalized.

Conclusion: The study demonstrated the effectiveness of a multidisciplinary pulmonary rehabilitation approach in improving program participation and achieving meaningful discharge outcomes. These findings underscore the potential for expanding multidisciplinary efforts and highlight the need for further studies to increase discharge-to-home rates and evaluate the long-term impacts of such programs.

  • 1,517 View
  • 54 Download

Review articles

Special topic: role of institutes related to the occupational and environmental diseases in Korea

[English]
Trauma counseling centers for psychological support to manage trauma from workplace injuries in Korea: a narrative review
Chang Sook Kim, Jeong-Ok Kong, Jung-Wan Koo
Ewha Med J 2025;48(1):e12.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e12

This review describes a psychological support service designed to address post-traumatic stress disorder in workers impacted by workplace injuries, assisting in their recovery and facilitating their return to work. It explores the rationale and context behind establishing trauma counseling centers for these individuals, along with the status, roles, future directions, and recommendations for these centers. The review details the operational framework and functions of the workplace injury trauma management program, the scope of the impacts of such injury, the groups targeted for crisis intervention, and the psychological interventions tailored to each stage of recovery. Initiated as a pilot project in 2018, trauma counseling centers for workers have gradually become more common, with 23 centers in operation across Korea as of 2024.

Citations

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  • The age of trauma: the prevalence and psychological impact of potentially traumatic exposures in South Korea
    Gaeun Son, Jihee Jang, Euntaek Hong, Subin Park, Yun-Kyeung Choi, Kee-Hong Choi
    Frontiers in Psychiatry.2025;[Epub]     CrossRef
  • 6,727 View
  • 33 Download
  • 1 Crossref

Special topic: recent clinical approach to shoulder diseases in older adults

[English]

Shoulder diseases, including adhesive capsulitis, rotator cuff tear, and osteoarthritis of the glenohumeral joint, can significantly impair daily activities in older adult patients. This review aims to examine the radiologic findings associated with these shoulder conditions in older patients, providing insights for accurate diagnosis and effective treatment. Adhesive capsulitis, commonly known as frozen shoulder, leads to pain and restricted movement, thereby causing shoulder dysfunction. Recent advances in diagnostic technology have greatly enhanced the sensitivity and accuracy of diagnosing this condition through radiologic evaluations, including MRI, magnetic resonance arthrography (MRA), and high-resolution ultrasound. Rotator cuff disease is another frequent issue in older adults, with full-thickness tears occurring in 50%–80% of cases. Both MRI and MRA are highly sensitive and specific in identifying rotator cuff tears. Additionally, ultrasonography is recognized for its high sensitivity and specificity in detecting tears of the supraspinatus tendon. Although osteoarthritis of the glenohumeral joint is less commonly prevalent, its advanced stages can severely affect the function of the upper extremity. Plain radiography is typically the first imaging technique used to assess this type of osteoarthritis. As the condition worsens, CT is utilized to measure glenoid bone loss, glenoid version, and inclination, which are crucial for accurate surgical planning. Each imaging modality provides distinct benefits: plain radiographs for initial structural assessment, ultrasonography for real-time evaluation of soft tissues, MRI/MRA for detailed visualization of capsular and tendinous lesions, and CT for precise bony analysis.

Citations

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  • Machine learning outperforms deep learning in adhesive capsulitis diagnosis: a clinical-radiomics model bridging PD-T2 MRI and multimodal data fusion
    Yang Yang, Ting Pan, Cong Zhang
    European Journal of Radiology.2025; 193: 112470.     CrossRef
  • 3,582 View
  • 66 Download
  • 1 Web of Science
  • 1 Crossref
[English]
Conservative treatment of older adult patients with shoulder diseases: a narrative review
Kook Jong Kim, Ho-Seung Jeong
Ewha Med J 2025;48(1):e1.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e1

The purpose of this review is to provide a comprehensive guide for managing older adult patients with shoulder diseases, specifically rotator cuff tears and osteoarthritis, and to explore effective nonsurgical treatment options. Chronic rotator cuff tears are typically degenerative, whereas acute tears result from trauma. A key feature of these tears is tendon degeneration accompanied by type III collagen predominance, predisposing tears to progression. Osteoarthritis in the glenohumeral joint arises from wear-and-tear changes that compromise cartilage integrity, leading to pain and restricted motion. Accurate clinical assessment and imaging, including plain radiographs, ultrasonography, and MRI, facilitate diagnosis and guide treatment. The physic-al examination emphasizes range of motion, rotator cuff strength, and scapular stability. Management strategies prioritize pain relief, function preservation, and improving mobility. Nonsurgical modalities, including exercise, manual therapy, and activity modification, constitute first-line treatments, especially for older adults. Pharmacological approaches involve NSAIDs, corticosteroid injections, and neuropathic pain medications. Steroid injections have short-term benefits, but repeated treatments may compromise tissue integrity. Platelet-rich plasma is a regenerative option that may improve tendon healing, but mixed findings highlight the need for further investigation. A structured physical therapy program focusing on range of motion and strengthening is essential, with alternative interventions used judiciously. Patients should be counseled regarding the potential progression of tears and the possible need for future surgical intervention if nonsurgical methods are unsuccessful. Multimodal approaches, including joint mobilization and personalized exercise regimens, hold potential for optimizing functional outcomes and supporting independence in older adults.

Citations

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  • Theranostic nanoparticles for osteoarthritis: Converging drug delivery and imaging toward personalised joint healthcare
    Roshan Keshari, Gayathri Muddala, Amarjitsing Rajput, Biji Balakrishnan, Navneet Kaur, Rohit Srivastava
    Journal of Drug Delivery Science and Technology.2026; 115: 107796.     CrossRef
  • 5,455 View
  • 70 Download
  • 1 Web of Science
  • 1 Crossref
[English]
Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis
Jeayeon Park, Su Jong Yu
Ewha Med J 2025;48(1):e4.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e4

Hepatocellular carcinoma with portal vein tumor thrombosis presents a significant therapeutic challenge due to its poor prognosis and limited treatment options. This review thoroughly examines diagnostic methods, including imaging techniques and classification systems such as the Japanese Vp and Cheng’s classifications, to aid in clinical decision-making. Treatment strategies encompass liver resection and liver transplantation, particularly living donor liver transplantation after successful downstaging, which have shown potential benefits in selected cases. Locoregional therapies, including hepatic arterial infusion chemotherapy, transarterial chemoembolization, transarterial radioembolization, and external beam radiation therapy, remain vital components of treatment. Recent advancements in systemic therapies, such as sorafenib, lenvatinib, and immune checkpoint inhibitors (e.g., atezolizumab plus bevacizumab) have demonstrated improvements in overall survival and progression-free survival. These developments underscore the importance of a multidisciplinary and personalized approach to improve outcomes for patients with hepatocellular carcinoma and portal vein tumor thrombosis.

  • 9,599 View
  • 137 Download
[English]
Prevalence and factors influencing postpartum depression and its culture-specific cutoffs for women in Asia: a scoping review
Bora Moon, Hyun Kyoung Kim, Ju-Hee Nho, Hyunkyung Choi, ChaeWeon Chung, Sook Jung Kang, Ju Hee Kim, Ju-Young Lee, Sihyun Park, Gisoo Shin, Ju-Eun Song, Min Hee Lee, Sue Kim
Ewha Med J 2025;48(1):e15.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e15

The prevalence of postpartum depression (PPD) in Asia is reported to range from 13.53% to 22.31%. However, there remains a gap in the identification of PPD, particularly regarding cultural cutoff points. Therefore, the purpose of this scoping review was to determine the prevalence and associated factors of PPD in Eastern, South-eastern, Western, and Southern Asian countries and analyze the cutoff points of the Edinburgh Postnatal Depression Scale (EPDS) used across these countries. Following Arksey and O'Malley’s five-step scoping review framework, the population was defined as mothers, the concept as the EPDS, and the context as the Asian region. A literature search was conducted using PubMed, Embase, CINAHL, PsycINFO, and Web of Science. The data analysis focused on demographic characteristics, EPDS cutoffs and features, PPD prevalence, and its associated factors. Nineteen studies were selected. Most countries used translated versions of the EPDS with demonstrated reliability and validity. The cutoff scores varied, with most using scores of 10 or higher. The prevalence of PPD ranged from 5.1% to 78.7%. Key associated factors for PPD included cultural factors such as relationships with in-laws and preferences for the newborn’s sex. To improve the accuracy of PPD screening in Asia, the EPDS should be used consistently, and appropriate cutoff criteria must be established. In addition, prevention strategies and programs that reflect the cultural characteristics and social context of Asia need to be developed for the early detection and prevention of PPD.

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  • 110 Download
[English]
Nutritional management for breast cancer patients
Minjeong Kim, Minkyoung Lee, Jisun Sa
Ewha Med J 2025;48(1):e11.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2025.e11

Breast cancer is a complex disease influenced by environmental, genetic, dietary, and hormonal factors. This underscores the importance of postoperative nutritional management in supporting recovery, minimizing complications, and enhancing long-term outcomes. This review synthesizes clinical guidelines, expert recommendations, and observational studies to provide a comprehensive overview of dietary interventions for breast cancer patients following surgery. Post-surgical nutritional care is centered around three primary objectives: supporting wound healing through high-quality protein intake, maintaining optimal nutritional status to prevent malnutrition, and promoting healthy lifestyle habits to reduce the risk of recurrence. To achieve these objectives, postoperative dietary strategies focus on several key components: ensuring adequate hydration for metabolic processes and tissue repair, consuming a balanced diet rich in fresh vegetables and fruits to mitigate oxidative stress, incorporating whole grains to support overall healing, and maintaining sufficient intake of high-quality protein from sources such as fish, meat, and dairy products to aid tissue repair and immune system recovery. Patients are also advised to avoid alcohol, limit saturated fats, and reduce intake of salty, sugary, and smoked foods to minimize inflammation. As research progresses, the implementation of personalized dietary plans remains essential for optimizing recovery outcomes in breast cancer patients.

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[English]
Sex differences in the prevalence of common comorbidities in autism: a narrative review
Yoo Hwa Hong, Da-Yea Song, Heejeong Yoo
Ewha Med J 2025;48(1):e79.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2024.e79

Autism spectrum disorder involves challenges in social communication and restricted, repetitive behaviors. Historically, males have received autism diagnoses at comparatively high rates, prompting an underrepresentation of females in research and an incomplete understanding of sex-specific symptom presentations and comorbidities. This review examines sex differences in the prevalence of common comorbidities of autism to inform tailored clinical practices. These conditions include attention deficit hyperactivity disorder, anxiety disorders, conduct disorder, depression, epilepsy, intellectual disability, and tic disorders. Attention deficit hyperactivity disorder is prevalent in both sexes; however, females may more frequently exhibit the inattentive subtype. Anxiety disorders display inconsistent sex differences, while conduct disorder more frequently impacts males. Depression becomes more common with age; some studies indicate more pronounced symptoms in adolescent girls, while others suggest greater severity in males. Epilepsy is more prevalent in females, especially those with intellectual disabilities. Despite displaying a male predominance, intellectual disability may exacerbate the severity of autism to a greater degree in females. No clear sex differences have been found regarding tic disorders. Overall, contributors to sex-based differences include biases stemming from male-centric diagnostic tools, compensatory behaviors like camouflaging in females, genetic and neurobiological differences, and the developmental trajectories of comorbidities. Recognizing these factors is crucial for developing sensitive diagnostics and sex-specific interventions. Inconsistencies in the literature highlight the need for longitudinal studies with large, diverse samples to investigate autism comorbidities across the lifespan. Understanding sex differences could facilitate earlier identification, improved care, and personalized interventions, thus enhancing quality of life for individuals with autism.

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  • Exploring Sociodemographic, Parental, and Temporal Correlates of Mental Health Disorders in Child and Adolescent Psychotherapy: A Clinic‐Based Investigation
    Esther Richter, Sara Edraki, Elke Humer
    Journal of Child and Adolescent Psychiatric Nursing.2025;[Epub]     CrossRef
  • 8,004 View
  • 75 Download
  • 1 Web of Science
  • 1 Crossref
Original Article
[English]
No difference in inflammatory mediator expression between mast cell-rich and mast cell-poor rosacea lesions in Korean patients: a comparative study
Jin Ju Lee, Bo Ram Kwon, Min Young Lee, Ji Yeon Byun, Joo Young Roh, Hae Young Choi, You Won Choi
Ewha Med J 2025;48(1):e78.   Published online January 31, 2025
DOI: https://doi.org/10.12771/emj.2024.e78

Objectives: This study aimed to evaluate the correlation between mast cell (MC) density in rosacea-affected skin and the expression of key inflammatory mediators, including IL-6, TNF-α, and cathelicidin LL-37. By comparing lesions rich in MCs with those having fewer MCs, we sought to elucidate the role of MCs in the inflammatory mechanisms underlying rosacea pathogenesis.

Methods: Specimens were collected from 20 patients diagnosed with rosacea who attended the outpatient clinic between 2008 and 2013. Each specimen underwent staining using hematoxylin/eosin, Giemsa, IL-6, LL-37, and TNF-α for both histopathological and immunohistochemical analyses. The number of stained cells was counted across 10 randomly selected dermal layers at a magnification of ×400 using light microscopy. The results were categorized based on the number of MCs counted: more than 10 MCs were classified as MC-rich, and 10 or fewer MCs as MC-poor.

Results: Among the 20 patients (10 MC-rich and 10 MC-poor), the MC-rich group demonstrated significantly higher MC counts than the MC-poor group (P<0.001). However, there were no significant differences in the expression levels of IL-6, LL-37, or TNF-α between the two groups. Additionally, MC density did not show any significant associations with patient demographics, clinical characteristics, or systemic comorbidities.

Conclusion: Increased MC density was not associated with differences in IL-6, TNF-α, or LL-37 expression in rosacea lesions. These findings suggest that MC infiltration may not directly influence the inflammatory mediator profile in rosacea. Further research is required to identify distinctive pathological features or markers that can elucidate the mechanisms of rosacea.

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